Obstructive Sleep Apnea, Glucose Tolerance, and β-Cell Function in Adults With Prediabetes or Untreated Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study
Obstructive sleep apnea (OSA) is associated with insulin resistance and has been described as a risk factor for type 2 diabetes. Whether OSA adversely impacts pancreatic islet β-cell function remains unclear. We aimed to investigate the association of OSA and short sleep duration with β-cell functio...
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| Published in | Diabetes care Vol. 44; no. 4; pp. 993 - 1001 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Diabetes Association
01.04.2021
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Obstructive sleep apnea (OSA) is associated with insulin resistance and has been described as a risk factor for type 2 diabetes. Whether OSA adversely impacts pancreatic islet β-cell function remains unclear. We aimed to investigate the association of OSA and short sleep duration with β-cell function in overweight/obese adults with prediabetes or recently diagnosed, treatment-naive type 2 diabetes.
Two hundred twenty-one adults (57.5% men, age 54.5 ± 8.7 years, BMI 35.1 ± 5.5 kg/m
) completed 1 week of wrist actigraphy and 1 night of polysomnography before undergoing a 3-h oral glucose tolerance test (OGTT) and a two-step hyperglycemic clamp. Associations of measures of OSA and actigraphy-derived sleep duration with HbA
, OGTT-derived outcomes, and clamp-derived outcomes were evaluated with adjusted regression models.
Mean ± SD objective sleep duration by actigraphy was 6.6 ± 1.0 h/night. OSA, defined as an apnea-hypopnea index (AHI) of five or more events per hour, was present in 89% of the participants (20% mild, 28% moderate, 41% severe). Higher AHI was associated with higher HbA
(
= 0.007). However, OSA severity, measured either by AHI as a continuous variable or by categories of OSA severity, and sleep duration (continuous or <6 vs. ≥6 h) were not associated with fasting glucose, 2-h glucose, insulin sensitivity, or β-cell responses.
In this baseline cross-sectional analysis of the RISE clinical trial of adults with prediabetes or recently diagnosed, untreated type 2 diabetes, the prevalence of OSA was high. Although some measures of OSA severity were associated with HbA
, OSA severity and sleep duration were not associated with measures of insulin sensitivity or β-cell responses. |
|---|---|
| AbstractList | Obstructive sleep apnea (OSA) is associated with insulin resistance and has been described as a risk factor for type 2 diabetes. Whether OSA adversely impacts pancreatic islet β-cell function remains unclear. We aimed to investigate the association of OSA and short sleep duration with β-cell function in overweight/obese adults with prediabetes or recently diagnosed, treatment-naive type 2 diabetes.
Two hundred twenty-one adults (57.5% men, age 54.5 ± 8.7 years, BMI 35.1 ± 5.5 kg/m
) completed 1 week of wrist actigraphy and 1 night of polysomnography before undergoing a 3-h oral glucose tolerance test (OGTT) and a two-step hyperglycemic clamp. Associations of measures of OSA and actigraphy-derived sleep duration with HbA
, OGTT-derived outcomes, and clamp-derived outcomes were evaluated with adjusted regression models.
Mean ± SD objective sleep duration by actigraphy was 6.6 ± 1.0 h/night. OSA, defined as an apnea-hypopnea index (AHI) of five or more events per hour, was present in 89% of the participants (20% mild, 28% moderate, 41% severe). Higher AHI was associated with higher HbA
(
= 0.007). However, OSA severity, measured either by AHI as a continuous variable or by categories of OSA severity, and sleep duration (continuous or <6 vs. ≥6 h) were not associated with fasting glucose, 2-h glucose, insulin sensitivity, or β-cell responses.
In this baseline cross-sectional analysis of the RISE clinical trial of adults with prediabetes or recently diagnosed, untreated type 2 diabetes, the prevalence of OSA was high. Although some measures of OSA severity were associated with HbA
, OSA severity and sleep duration were not associated with measures of insulin sensitivity or β-cell responses. OBJECTIVE Obstructive sleep apnea (OSA) is associated with insulin resistance and has been described as a risk factor for type 2 diabetes. Whether OSA adversely impacts pancreatic islet β-cell function remains unclear. We aimed to investigate the association of OSA and short sleep duration with β-cell function in overweight/obese adults with prediabetes or recently diagnosed, treatment-naive type 2 diabetes. RESEARCH DESIGN AND METHODS Two hundred twenty-one adults (57.5% men, age 54.5 ± 8.7 years, BMI 35.1 ± 5.5 kg/m2) completed 1 week of wrist actigraphy and 1 night of polysomnography before undergoing a 3-h oral glucose tolerance test (OGTT) and a two-step hyperglycemic clamp. Associations of measures of OSA and actigraphy-derived sleep duration with HbA1c, OGTT-derived outcomes, and clamp-derived outcomes were evaluated with adjusted regression models. RESULTS Mean ± SD objective sleep duration by actigraphy was 6.6 ± 1.0 h/night. OSA, defined as an apnea-hypopnea index (AHI) of five or more events per hour, was present in 89% of the participants (20% mild, 28% moderate, 41% severe). Higher AHI was associated with higher HbA1c (P = 0.007). However, OSA severity, measured either by AHI as a continuous variable or by categories of OSA severity, and sleep duration (continuous or <6 vs. ≥6 h) were not associated with fasting glucose, 2-h glucose, insulin sensitivity, or β-cell responses. CONCLUSIONS In this baseline cross-sectional analysis of the RISE clinical trial of adults with prediabetes or recently diagnosed, untreated type 2 diabetes, the prevalence of OSA was high. Although some measures of OSA severity were associated with HbA1c, OSA severity and sleep duration were not associated with measures of insulin sensitivity or β-cell responses. OBJECTIVE Obstructive sleep apnea (OSA) is associated with insulin resistance and has been described as a risk factor for type 2 diabetes. Whether OSA adversely impacts pancreatic islet β-cell function remains unclear. We aimed to investigate the association of OSA and short sleep duration with β-cell function in overweight/obese adults with prediabetes or recently diagnosed, treatment-naive type 2 diabetes. RESEARCH DESIGN AND METHODS Two hundred twenty-one adults (57.5% men, age 54.5 ± 8.7 years, BMI 35.1 ± 5.5 kg/m2) completed 1 week of wrist actigraphy and 1 night of polysomnography before undergoing a 3-h oral glucose tolerance test (OGTT) and a two-step hyperglycemic clamp. Associations of measures of OSA and actigraphy-derived sleep duration with HbA1c, OGTT-derived outcomes, and clamp-derived outcomes were evaluated with adjusted regression models. RESULTS Mean ± SD objective sleep duration by actigraphy was 6.6 ± 1.0 h/night. OSA, defined as an apnea-hypopnea index (AHI) of five or more events per hour, was present in 89% of the participants (20% mild, 28% moderate, 41% severe). Higher AHI was associated with higher HbA1c (P = 0.007). However, OSA severity, measured either by AHI as a continuous variable or by categories of OSA severity, and sleep duration (continuous or <6 vs. ≥6 h) were not associated with fasting glucose, 2-h glucose, insulin sensitivity, or β-cell responses. CONCLUSIONS In this baseline cross-sectional analysis of the RISE clinical trial of adults with prediabetes or recently diagnosed, untreated type 2 diabetes, the prevalence of OSA was high. Although some measures of OSA severity were associated with HbA1c, OSA severity and sleep duration were not associated with measures of insulin sensitivity or β-cell responses. OBJECTIVEObstructive sleep apnea (OSA) is associated with insulin resistance and has been described as a risk factor for type 2 diabetes. Whether OSA adversely impacts pancreatic islet β-cell function remains unclear. We aimed to investigate the association of OSA and short sleep duration with β-cell function in overweight/obese adults with prediabetes or recently diagnosed, treatment-naive type 2 diabetes. RESEARCH DESIGN AND METHODSTwo hundred twenty-one adults (57.5% men, age 54.5 ± 8.7 years, BMI 35.1 ± 5.5 kg/m2) completed 1 week of wrist actigraphy and 1 night of polysomnography before undergoing a 3-h oral glucose tolerance test (OGTT) and a two-step hyperglycemic clamp. Associations of measures of OSA and actigraphy-derived sleep duration with HbA1c, OGTT-derived outcomes, and clamp-derived outcomes were evaluated with adjusted regression models. RESULTSMean ± SD objective sleep duration by actigraphy was 6.6 ± 1.0 h/night. OSA, defined as an apnea-hypopnea index (AHI) of five or more events per hour, was present in 89% of the participants (20% mild, 28% moderate, 41% severe). Higher AHI was associated with higher HbA1c (P = 0.007). However, OSA severity, measured either by AHI as a continuous variable or by categories of OSA severity, and sleep duration (continuous or <6 vs. ≥6 h) were not associated with fasting glucose, 2-h glucose, insulin sensitivity, or β-cell responses. CONCLUSIONSIn this baseline cross-sectional analysis of the RISE clinical trial of adults with prediabetes or recently diagnosed, untreated type 2 diabetes, the prevalence of OSA was high. Although some measures of OSA severity were associated with HbA1c, OSA severity and sleep duration were not associated with measures of insulin sensitivity or β-cell responses. |
| Author | Temple, Karla A Tjaden, Ashley H Manchanda, Shalini Nadeau, Kristen J Ehrmann, David A Mokhlesi, Babak Sam, Susan Hannon, Tamara S Edelstein, Sharon L Mather, Kieren J Kahn, Steven E Van Cauter, Eve |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33547205$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1111/dom.12823 10.1111/dom.13005 10.1016/j.smrv.2015.10.002 10.1164/rccm.200504-637OC 10.2337/dc19-0556 10.2337/dc13-1879 10.1161/JAHA.119.013209 10.2337/diab.42.11.1663 10.2337/dc18-0244 10.1007/s11325-016-1428-7 10.2337/dc19-0538 10.1172/JCI105534 10.1164/rccm.201408-1564OC 10.2337/dc13-0933 10.1073/pnas.0706446105 10.1038/nature05482 10.1164/rccm.201511-2260OC 10.7326/0003-4819-157-8-201210160-00005 10.1007/BF00280883 10.2337/dc09-1124 10.2337/diacare.19.3.278 10.1164/rccm.200302-206OC 10.1016/S0140-6736(99)01376-8 10.1164/rccm.200809-1392OC 10.5664/jcsm.27387 10.1001/jama.2018.3060 10.1164/rccm.201602-0396LE 10.1164/rccm.201510-1942OC 10.1007/s11325-016-1388-y 10.1111/j.1464-5491.1994.tb00273.x 10.1016/j.chest.2017.05.009 10.1016/j.amjmed.2009.04.026 10.2337/dc18-S002 10.2337/dc19-2006 10.5665/sleep.4998 10.1016/S2213-2600(15)00043-0 10.1152/japplphysiol.91523.2008 10.2337/dc07-2003 |
| ContentType | Journal Article |
| Contributor | Temple, Karla A Chisholm, Robin Nayak, Krishan Buchanan, Thomas A Rue, Abby Williams, Jayne Albers, John Martinez, Mayra Ehrmann, David A Lteif, Amale Sam, Susan Patel, Aniket Hendee, Fadi N Porter, Kristin Kernan-Schloss, Abigail Palmer, Jerry P Savoye, Mary Pierpont, Bridget Miller, M Annette Leschek, Ellen W Moore, Karen Barengolts, Elena Montgomery, Brenda K Kozedub, Alexandra Pirics, Vivian Caprio, Sonia Guerra, Nancy Montgomery, Cortney Garrett, Tammy Atkinson, Karen M Trigo, Enrique Lachin, John M Hannon, Tamara S Mokhlesi, Babak Mather, Kieren J Gross, Susan Wang, Xinhui Katkhouda, Namir Van Cauter, Eve Xiang, Anny H Gebremedhin, Tsige Beale, Elizabeth Edelstein, Sharon L Tjaden, Ashley Hogan Pratt, Linda Arslanian, Silva A Tjaden, Ashley H Nadeau, Kristen J Marcovina, Santica Harting, Jessica Kahn, Steven E Cree-Green, Melanie Morse, Emily J Brown, Kathleen Savage, Peter J Hill, Dave Utzschneider, Kristina M Vissat, Krista Zeitler, Philip S Reyes, Yesenia Garcia |
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| Copyright | 2021 by the American Diabetes Association. Copyright American Diabetes Association Apr 1, 2021 2021 by the American Diabetes Association 2021 |
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| References | Temple (2022031309374996400_B13) 2019; 42 Loffler (2022031309374996400_B39) 2020; 43 Mokhlesi (2022031309374996400_B36) 2017; 19 Patel (2022031309374996400_B12) 2015; 38 Yano (2022031309374996400_B25) 2020; 9 Shaw (2022031309374996400_B32) 2016; 194 Seicean (2022031309374996400_B24) 2008; 31 Reutrakul (2022031309374996400_B4) 2017; 152 Louis (2022031309374996400_B8) 2009; 106 RISE Consortium (2022031309374996400_B15) 2018; 41 Hales (2022031309374996400_B2) 2018; 319 Seltzer (2022031309374996400_B18) 1967; 46 2022031309374996400_B1 Phillips (2022031309374996400_B17) 1994; 11 Anothaisintawee (2022031309374996400_B22) 2016; 30 Pamidi (2022031309374996400_B37) 2015; 192 Harsch (2022031309374996400_B30) 2004; 169 RISE Consortium (2022031309374996400_B11) 2014; 37 Tasali (2022031309374996400_B7) 2008; 105 Punjabi (2022031309374996400_B26) 2009; 179 Cappuccio (2022031309374996400_B23) 2010; 33 Kahn (2022031309374996400_B21) 1993; 42 Hannon (2022031309374996400_B14) 2018; 20 Broussard (2022031309374996400_B6) 2012; 157 Grimaldi (2022031309374996400_B38) 2014; 37 RISE Consortium (2022031309374996400_B10) 2019; 42 Mokhlesi (2022031309374996400_B35) 2016; 194 Morariu (2022031309374996400_B33) 2017; 21 Elahi (2022031309374996400_B20) 1996; 19 Reichmuth (2022031309374996400_B29) 2005; 172 Martínez-Cerón (2022031309374996400_B31) 2016; 194 Heinzer (2022031309374996400_B3) 2015; 3 Spiegel (2022031309374996400_B5) 1999; 354 Kahn (2022031309374996400_B9) 2006; 444 Matthews (2022031309374996400_B19) 1985; 28 Lam (2022031309374996400_B34) 2017; 21 Botros (2022031309374996400_B27) 2009; 122 Marshall (2022031309374996400_B28) 2009; 5 American Diabetes Association (2022031309374996400_B16) 2018; 41 |
| References_xml | – volume: 19 start-page: 452 year: 2017 ident: 2022031309374996400_B36 article-title: Effect of one week of CPAP treatment of obstructive sleep apnoea on 24-hour profiles of glucose, insulin and counter-regulatory hormones in type 2 diabetes publication-title: Diabetes Obes Metab doi: 10.1111/dom.12823 contributor: fullname: Mokhlesi – volume: 20 start-page: 14 year: 2018 ident: 2022031309374996400_B14 article-title: Review of methods for measuring β-cell function: design considerations from the Restoring Insulin Secretion (RISE) Consortium publication-title: Diabetes Obes Metab doi: 10.1111/dom.13005 contributor: fullname: Hannon – volume: 30 start-page: 11 year: 2016 ident: 2022031309374996400_B22 article-title: Sleep disturbances compared to traditional risk factors for diabetes development: systematic review and meta-analysis publication-title: Sleep Med Rev doi: 10.1016/j.smrv.2015.10.002 contributor: fullname: Anothaisintawee – volume: 172 start-page: 1590 year: 2005 ident: 2022031309374996400_B29 article-title: Association of sleep apnea and type II diabetes: a population-based study publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200504-637OC contributor: fullname: Reichmuth – volume: 42 start-page: 1742 year: 2019 ident: 2022031309374996400_B10 article-title: Lack of durable improvements in β-cell function following withdrawal of pharmacological interventions in adults with impaired glucose tolerance or recently diagnosed type 2 diabetes publication-title: Diabetes Care doi: 10.2337/dc19-0556 contributor: fullname: RISE Consortium – volume: 37 start-page: 780 year: 2014 ident: 2022031309374996400_B11 article-title: Restoring Insulin Secretion (RISE): design of studies of β-cell preservation in prediabetes and early type 2 diabetes across the life span publication-title: Diabetes Care doi: 10.2337/dc13-1879 contributor: fullname: RISE Consortium – volume: 9 start-page: e013209 year: 2020 ident: 2022031309374996400_B25 article-title: Sleep characteristics and measures of glucose metabolism in blacks: The Jackson Heart Study publication-title: J Am Heart Assoc doi: 10.1161/JAHA.119.013209 contributor: fullname: Yano – volume: 42 start-page: 1663 year: 1993 ident: 2022031309374996400_B21 article-title: Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function publication-title: Diabetes doi: 10.2337/diab.42.11.1663 contributor: fullname: Kahn – volume: 41 start-page: 1696 year: 2018 ident: 2022031309374996400_B15 article-title: Metabolic contrasts between youth and adults with impaired glucose tolerance or recently diagnosed type 2 diabetes: I. Observations using the hyperglycemic clamp publication-title: Diabetes Care doi: 10.2337/dc18-0244 contributor: fullname: RISE Consortium – volume: 21 start-page: 377 year: 2017 ident: 2022031309374996400_B34 article-title: CPAP therapy for patients with sleep apnea and type 2 diabetes mellitus improves control of blood pressure publication-title: Sleep Breath doi: 10.1007/s11325-016-1428-7 contributor: fullname: Lam – volume: 42 start-page: 1521 year: 2019 ident: 2022031309374996400_B13 article-title: Association of habitual daily physical activity with glucose tolerance and β-cell function in adults with impaired glucose tolerance or recently diagnosed type 2 diabetes from the Restoring Insulin Secretion (RISE) Study publication-title: Diabetes Care doi: 10.2337/dc19-0538 contributor: fullname: Temple – volume: 46 start-page: 323 year: 1967 ident: 2022031309374996400_B18 article-title: Insulin secretion in response to glycemic stimulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus publication-title: J Clin Invest doi: 10.1172/JCI105534 contributor: fullname: Seltzer – volume: 192 start-page: 96 year: 2015 ident: 2022031309374996400_B37 article-title: Eight hours of nightly continuous positive airway pressure treatment of obstructive sleep apnea improves glucose metabolism in patients with prediabetes. A randomized controlled trial publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201408-1564OC contributor: fullname: Pamidi – volume: 37 start-page: 355 year: 2014 ident: 2022031309374996400_B38 article-title: Association of obstructive sleep apnea in rapid eye movement sleep with reduced glycemic control in type 2 diabetes: therapeutic implications publication-title: Diabetes Care doi: 10.2337/dc13-0933 contributor: fullname: Grimaldi – volume: 105 start-page: 1044 year: 2008 ident: 2022031309374996400_B7 article-title: Slow-wave sleep and the risk of type 2 diabetes in humans publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0706446105 contributor: fullname: Tasali – volume: 444 start-page: 840 year: 2006 ident: 2022031309374996400_B9 article-title: Mechanisms linking obesity to insulin resistance and type 2 diabetes publication-title: Nature doi: 10.1038/nature05482 contributor: fullname: Kahn – volume: 194 start-page: 486 year: 2016 ident: 2022031309374996400_B32 article-title: The effect of treatment of obstructive sleep apnea on glycemic control in type 2 diabetes publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201511-2260OC contributor: fullname: Shaw – volume: 157 start-page: 549 year: 2012 ident: 2022031309374996400_B6 article-title: Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study publication-title: Ann Intern Med doi: 10.7326/0003-4819-157-8-201210160-00005 contributor: fullname: Broussard – volume: 28 start-page: 412 year: 1985 ident: 2022031309374996400_B19 article-title: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man publication-title: Diabetologia doi: 10.1007/BF00280883 contributor: fullname: Matthews – volume: 33 start-page: 414 year: 2010 ident: 2022031309374996400_B23 article-title: Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis publication-title: Diabetes Care doi: 10.2337/dc09-1124 contributor: fullname: Cappuccio – volume: 19 start-page: 278 year: 1996 ident: 2022031309374996400_B20 article-title: In praise of the hyperglycemic clamp. A method for assessment of beta-cell sensitivity and insulin resistance publication-title: Diabetes Care doi: 10.2337/diacare.19.3.278 contributor: fullname: Elahi – volume: 169 start-page: 156 year: 2004 ident: 2022031309374996400_B30 article-title: Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200302-206OC contributor: fullname: Harsch – volume: 354 start-page: 1435 year: 1999 ident: 2022031309374996400_B5 article-title: Impact of sleep debt on metabolic and endocrine function publication-title: Lancet doi: 10.1016/S0140-6736(99)01376-8 contributor: fullname: Spiegel – ident: 2022031309374996400_B1 – volume: 179 start-page: 235 year: 2009 ident: 2022031309374996400_B26 article-title: Alterations in glucose disposal in sleep-disordered breathing publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200809-1392OC contributor: fullname: Punjabi – volume: 5 start-page: 15 year: 2009 ident: 2022031309374996400_B28 article-title: Is sleep apnea an independent risk factor for prevalent and incident diabetes in the Busselton Health Study publication-title: J Clin Sleep Med doi: 10.5664/jcsm.27387 contributor: fullname: Marshall – volume: 319 start-page: 1723 year: 2018 ident: 2022031309374996400_B2 article-title: Trends in obesity and severe obesity prevalence in US youth and adults by sex and age, 2007-2008 to 2015-2016 publication-title: JAMA doi: 10.1001/jama.2018.3060 contributor: fullname: Hales – volume: 194 start-page: 516 year: 2016 ident: 2022031309374996400_B35 article-title: Effect of one week of 8-hour nightly continuous positive airway pressure treatment of obstructive sleep apnea on glycemic control in type 2 diabetes: a proof-of-concept study publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201602-0396LE contributor: fullname: Mokhlesi – volume: 194 start-page: 476 year: 2016 ident: 2022031309374996400_B31 article-title: Effect of continuous positive airway pressure on glycemic control in patients with obstructive sleep apnea and type 2 diabetes. A randomized clinical trial publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201510-1942OC contributor: fullname: Martínez-Cerón – volume: 21 start-page: 145 year: 2017 ident: 2022031309374996400_B33 article-title: Effect of continuous positive airway pressure (CPAP) on glycemic control and variability in type 2 diabetes publication-title: Sleep Breath doi: 10.1007/s11325-016-1388-y contributor: fullname: Morariu – volume: 11 start-page: 286 year: 1994 ident: 2022031309374996400_B17 article-title: Understanding oral glucose tolerance: comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion publication-title: Diabet Med doi: 10.1111/j.1464-5491.1994.tb00273.x contributor: fullname: Phillips – volume: 152 start-page: 1070 year: 2017 ident: 2022031309374996400_B4 article-title: Obstructive sleep apnea and diabetes: a state of the art review publication-title: Chest doi: 10.1016/j.chest.2017.05.009 contributor: fullname: Reutrakul – volume: 122 start-page: 1122 year: 2009 ident: 2022031309374996400_B27 article-title: Obstructive sleep apnea as a risk factor for type 2 diabetes publication-title: Am J Med doi: 10.1016/j.amjmed.2009.04.026 contributor: fullname: Botros – volume: 41 start-page: S13 year: 2018 ident: 2022031309374996400_B16 article-title: 2. Classification and diagnosis of diabetes: Standards of Medical Care in Diabetes—2018 publication-title: Diabetes Care doi: 10.2337/dc18-S002 contributor: fullname: American Diabetes Association – volume: 43 start-page: 1859 year: 2020 ident: 2022031309374996400_B39 article-title: Continuous positive airway pressure treatment, glycemia, and diabetes risk in obstructive sleep apnea and comorbid cardiovascular disease publication-title: Diabetes Care doi: 10.2337/dc19-2006 contributor: fullname: Loffler – volume: 38 start-page: 1497 year: 2015 ident: 2022031309374996400_B12 article-title: Reproducibility of a standardized actigraphy scoring algorithm for sleep in a US Hispanic/Latino population publication-title: Sleep (Basel) doi: 10.5665/sleep.4998 contributor: fullname: Patel – volume: 3 start-page: 310 year: 2015 ident: 2022031309374996400_B3 article-title: Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study publication-title: Lancet Respir Med doi: 10.1016/S2213-2600(15)00043-0 contributor: fullname: Heinzer – volume: 106 start-page: 1538 year: 2009 ident: 2022031309374996400_B8 article-title: Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers publication-title: J Appl Physiol (1985) doi: 10.1152/japplphysiol.91523.2008 contributor: fullname: Louis – volume: 31 start-page: 1001 year: 2008 ident: 2022031309374996400_B24 article-title: Sleep-disordered breathing and impaired glucose metabolism in normal-weight and overweight/obese individuals: the Sleep Heart Health Study publication-title: Diabetes Care doi: 10.2337/dc07-2003 contributor: fullname: Seicean |
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| Snippet | Obstructive sleep apnea (OSA) is associated with insulin resistance and has been described as a risk factor for type 2 diabetes. Whether OSA adversely impacts... OBJECTIVE Obstructive sleep apnea (OSA) is associated with insulin resistance and has been described as a risk factor for type 2 diabetes. Whether OSA... OBJECTIVE Obstructive sleep apnea (OSA) is associated with insulin resistance and has been described as a risk factor for type 2 diabetes. Whether OSA... OBJECTIVEObstructive sleep apnea (OSA) is associated with insulin resistance and has been described as a risk factor for type 2 diabetes. Whether OSA adversely... |
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| SubjectTerms | Adult Adults Apnea Beta cells Blood Glucose Body weight Continuity (mathematics) Cross-Sectional Studies Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 Female Glucose Glucose tolerance Humans Insulin Insulin resistance Insulin Secretion Male Middle Aged Night Pancreas Pathophysiology/Complications Prediabetic State Regression analysis Regression models Research design Risk analysis Risk factors Sleep Sleep apnea Sleep Apnea, Obstructive Sleep disorders Wrist |
| Title | Obstructive Sleep Apnea, Glucose Tolerance, and β-Cell Function in Adults With Prediabetes or Untreated Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study |
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