Impact of Laparoscopic Sleeve Gastrectomy on Gut Permeability in Morbidly Obese Subjects

• Published in: Obesity surgery Vol. 29; no. 7; pp. 2132 - 2143
• Main Authors: Kellerer, Teresa, Brandl, Beate, Büttner, Janine, Lagkouvardos, Ilias, Hauner, Hans, Skurk, Thomas
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2019; Springer Nature B.V
• Subjects: Adult; Biomarkers - blood; Body Mass Index; C-Reactive Protein - metabolism; Case-Control Studies; Female; Gastrectomy - adverse effects; Gastrectomy - methods; Gastrointestinal Microbiome - physiology; Gastrointestinal surgery; Humans; Inflammation - blood; Inflammation - complications; Inflammation - microbiology; Inflammation - surgery; Inflammation Mediators - blood; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; Intestinal Mucosa - pathology; Intestines - microbiology; Intestines - pathology; Intestines - surgery; Laparoscopy; Laparoscopy - adverse effects; Laparoscopy - methods; Male; Medicine; Medicine & Public Health; Metabolism; Microbiota; Middle Aged; Morbidity; Obesity; Obesity, Morbid - complications; Obesity, Morbid - metabolism; Obesity, Morbid - microbiology; Obesity, Morbid - surgery; Original Contributions; Permeability; Pilot Projects; Surgery; Weight control; Weight Loss - physiology; Gut microbiota; Obesity; Intestinal permeability; Sleeve gastrectomy

Background Recent studies have suggested that obesity is associated with an increased intestinal permeability as well as an altered microbiota profile. These conditions can promote the translocation of lipopolysaccharide into the circulation and, subsequently, contribute to the observed systemic inf...