Rational fusion design inspired by cell-penetrating peptide: SS31/S-14 G Humanin hybrid peptide with amplified multimodal efficacy and bio-permeability for the treatment of Alzheimer's disease

• Published in: Asian journal of pharmceutical sciences Vol. 19; no. 4; p. 100938
• Main Authors: Qian, Kang, Yang, Peng, Li, Yixian, Meng, Ran, Cheng, Yunlong, Zhou, Lingling, Wu, Jing, Xu, Shuting, Bao, Xiaoyan, Guo, Qian, Wang, Pengzhen, Xu, Minjun, Sheng, Dongyu, Zhang, Qizhi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2024; Shenyang Pharmaceutical University; Elsevier
• Subjects: Alzheimer's disease; Hybrid peptide; Permeability; S-14 G Humanin; SS31; SS31; Hybrid peptide; Aβ; Permeability; Alzheimer's disease; S-14 G Humanin

Alzheimer's disease is a neurodegenerative disease induced by multiple interconnected mechanisms. Peptide drug candidates with multi-modal efficacy generated from fusion strategy are suitable for addressing multi-facet pathology. However, clinical translation of peptide drugs is greatly hampere...