Engineering human islet organoids from iPSCs using an organ-on-chip platform

• Published in: Lab on a chip Vol. 19; no. 6; pp. 948 - 958
• Main Authors: Tao, Tingting, Wang, Yaqing, Chen, Wenwen, Li, Zhongyu, Su, Wentao, Guo, Yaqiong, Deng, Pengwei, Qin, Jianhua
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 13.03.2019
• Subjects: Biomimetics; Calcium ions; Culture; Diabetes mellitus; Differentiation (biology); Gene expression; Insulin; Medicine; Microfluidic devices; Modelling; Multilayers; Organic chemistry; Proteins; Stem cells

Human pluripotent stem cell (hPSC)-derived islet cells provide promising resources for diabetes studies, cell replacement treatment and drug screening. Recently, hPSC-derived organoids have represented a new class of in vitro organ models for disease modeling and regenerative medicine. However, rebu...