Glucose Effectiveness in Obese Children: Relation to Degree of Obesity and Dysglycemia

• Published in: Diabetes care Vol. 38; no. 4; pp. 689 - 695
• Main Authors: Weiss, Ram, Magge, Sheela N., Santoro, Nicola, Giannini, Cosimo, Boston, Raymond, Holder, Tara, Shaw, Melissa, Duran, Elvira, Hershkop, Karen J., Caprio, Sonia
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.04.2015
• Subjects: Adolescent; Blood Glucose - metabolism; Body Weight; Child; Children & youth; Cohort Studies; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - metabolism; Female; Glucose; Glucose Intolerance - complications; Glucose Intolerance - diagnosis; Glucose Intolerance - metabolism; Glucose Metabolism Disorders - complications; Glucose Metabolism Disorders - diagnosis; Glucose Metabolism Disorders - metabolism; Glucose Tolerance Test - methods; Humans; Male; Metabolism; Obesity; Pathophysiology/Complications; Pediatric Obesity - complications; Pediatric Obesity - metabolism; Prognosis; Severity of Illness Index; Waist Circumference

Impaired glucose effectiveness (GE) plays a role in the deterioration of glucose metabolism. Our aim was to validate a surrogate of GE derived from an oral glucose tolerance test (OGTT) and to assess the impact of degrees of obesity and of glucose tolerance on it. The OGTT-derived surrogate of GE (o...