Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB104:01

• Published in: Diabetes (New York, N.Y.) Vol. 69; no. 7; pp. 1492 - 1502
• Main Authors: Arribas-Layton, David, Guyer, Perrin, Delong, Thomas, Dang, Mylinh, Chow, I-Ting, Speake, Cate, Greenbaum, Carla J., Kwok, William W., Baker, Rocky L., Haskins, Kathryn, James, Eddie A.
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.07.2020
• Subjects: CD4-Positive T-Lymphocytes - immunology; Cross Reactions; Cytokines; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - immunology; Drb1 protein; Epitopes; HLA-DRB1 Chains - immunology; Humans; Immunological memory; Immunological tolerance; Immunology and Transplantation; Insulin; Insulin - chemistry; Insulin - immunology; Insulin-Secreting Cells - immunology; Lymphocytes; Lymphocytes T; Mass spectroscopy; Organ donors; Pancreas; Peptide Fragments - chemistry; Peptide Fragments - immunology; Peptides; Peripheral blood; Phenotypes; T-Lymphocytes - immunology

T cells isolated from the pancreatic infiltrates of nonobese diabetic mice have been shown to recognize epitopes formed by the covalent cross-linking of proinsulin and secretory granule peptides. Formation of such hybrid insulin peptides (HIPs) was confirmed through mass spectrometry, and responses...