Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning

• Published in: Scientific reports Vol. 6; no. 1; p. 22529
• Main Authors: Chang, Ching-Pang, Lee, Cheng-Ta, Hou, Wen-Hsien, Lin, Meng-Syuan, Lai, Hsing-Lin, Chien, Chen-Li, Chang, Chen, Cheng, Pei-Lin, Lien, Cheng-Chang, Chern, Yijuang
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 02.03.2016
• Subjects: Adenylyl Cyclases - genetics; Adenylyl Cyclases - metabolism; Anatomy; Animals; Calcium signalling; Cyclic AMP response element-binding protein; Glutamic acid receptors (ionotropic); Hippocampus; Hippocampus - enzymology; Hippocampus - metabolism; Learning; Long-term depression; Long-Term Synaptic Depression - physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methyl-D-aspartic acid receptors; N-Terminus; Plasticity (neural); Receptors, N-Methyl-D-Aspartate - physiology; Reversal learning; Rodents; Spatial discrimination learning

The calcium-sensitive type VI adenylyl cyclase (AC6) is a membrane-bound adenylyl cyclase (AC) that converts ATP to cAMP under stimulation. It is a calcium-inhibited AC and integrates negative inputs from Ca(2+) and multiple other signals to regulate the intracellular cAMP level. In the present stud...