Prognostic Significance of Kit Receptor Tyrosine Kinase Dysregulations in Feline Cutaneous Mast Cell Tumors

• Published in: Veterinary pathology Vol. 50; no. 5; pp. 797 - 805
• Main Authors: Sabattini, S., Frizzon, M. Guadagni, Gentilini, F., Turba, M. E., Capitani, O., Bettini, G.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.09.2013
• Subjects: Animals; Cat Diseases - enzymology; Cat Diseases - metabolism; Cats; DNA Mutational Analysis - veterinary; Gene Expression Regulation, Enzymologic - physiology; Gene Expression Regulation, Neoplastic - physiology; Histological Techniques - veterinary; Immunohistochemistry - veterinary; Italy; Mastocytosis, Cutaneous - enzymology; Mastocytosis, Cutaneous - metabolism; Mastocytosis, Cutaneous - veterinary; Proto-Oncogene Proteins c-kit - metabolism; ROC Curve; Italy; mutation; feline; c-Kit; Kit protein; cat; CD117; mast cell tumor; prognosis

Feline cutaneous mast cell tumors (FeCMCTs) are characterized by variable biological behavior. Development of multiple nodules and potential visceral involvement, along with inconsistency of conventional prognostic aids, justify uncertainty in differentiating benign from malignant forms. c-Kit proto...