The role of SARS-CoV-2-mediated NF-κB activation in COVID-19 patients

The SARS-CoV-2 pandemic, now in its third year, has had a profound impact on public health and economics all over the world. Different populations showed varied susceptibility to this virus and mortality after infection. Clinical and laboratory data revealed that the uncontrolled inflammatory respon...

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Published inHypertension research Vol. 47; no. 2; pp. 375 - 384
Main Authors Zhou, Qiaoqiao, Zhang, Lei, Dong, Yanming, Wang, Yuan, Zhang, Bin, Zhou, Shiyi, Huang, Qing, Wu, Tian, Chen, Gongxuan
Format Journal Article
LanguageEnglish
Published England Springer Nature Singapore 01.02.2024
Subjects
COVID-19
Humans
NF-kappa B - metabolism
Peptidyl-Dipeptidase A - metabolism
Review
SARS-CoV-2
Signal Transduction
COVID-19
Inflammatory response
NF-κB activation
SARS-CoV-2
COVID-19 drugs
Online AccessGet full text

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Abstract The SARS-CoV-2 pandemic, now in its third year, has had a profound impact on public health and economics all over the world. Different populations showed varied susceptibility to this virus and mortality after infection. Clinical and laboratory data revealed that the uncontrolled inflammatory response plays an important role in their poor outcome. Herein, we summarized the role of NF-κB activation during SARS-CoV-2 invasion and replication, particularly the angiotensin-converting enzyme 2 (ACE2)-mediated NF-κB activation. Then we summarized the COVID-19 drugs' impact on NF-κB activation and their problems. A favorable prognosis is linked with timely treatment with NF-κB activation inhibitors, such as TNFα, IL-1β, and IL-6 monoclonal antibodies. However, further clinical researches are still required to clarify the time window, dosage of administration, contraindication, and potential side effects of these drugs, particularly for COVID-19 patients with hypertension, hyperglycemia, diabetes, or other chronic diseases.
AbstractList The SARS-CoV-2 pandemic, now in its third year, has had a profound impact on public health and economics all over the world. Different populations showed varied susceptibility to this virus and mortality after infection. Clinical and laboratory data revealed that the uncontrolled inflammatory response plays an important role in their poor outcome. Herein, we summarized the role of NF-κB activation during SARS-CoV-2 invasion and replication, particularly the angiotensin-converting enzyme 2 (ACE2)-mediated NF-κB activation. Then we summarized the COVID-19 drugs' impact on NF-κB activation and their problems. A favorable prognosis is linked with timely treatment with NF-κB activation inhibitors, such as TNFα, IL-1β, and IL-6 monoclonal antibodies. However, further clinical researches are still required to clarify the time window, dosage of administration, contraindication, and potential side effects of these drugs, particularly for COVID-19 patients with hypertension, hyperglycemia, diabetes, or other chronic diseases.
Abstract The SARS-CoV-2 pandemic, now in its third year, has had a profound impact on public health and economics all over the world. Different populations showed varied susceptibility to this virus and mortality after infection. Clinical and laboratory data revealed that the uncontrolled inflammatory response plays an important role in their poor outcome. Herein, we summarized the role of NF-κB activation during SARS-CoV-2 invasion and replication, particularly the angiotensin-converting enzyme 2 (ACE2)-mediated NF-κB activation. Then we summarized the COVID-19 drugs’ impact on NF-κB activation and their problems. A favorable prognosis is linked with timely treatment with NF-κB activation inhibitors, such as TNFα, IL-1β, and IL-6 monoclonal antibodies. However, further clinical researches are still required to clarify the time window, dosage of administration, contraindication, and potential side effects of these drugs, particularly for COVID-19 patients with hypertension, hyperglycemia, diabetes, or other chronic diseases.
Author Huang, Qing
Dong, Yanming
Chen, Gongxuan
Zhou, Qiaoqiao
Wang, Yuan
Zhang, Bin
Wu, Tian
Zhang, Lei
Zhou, Shiyi
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Issue 2
Keywords COVID-19
Inflammatory response
NF-κB activation
SARS-CoV-2
COVID-19 drugs
Language English
License 2023. The Author(s).
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Snippet The SARS-CoV-2 pandemic, now in its third year, has had a profound impact on public health and economics all over the world. Different populations showed...
Abstract The SARS-CoV-2 pandemic, now in its third year, has had a profound impact on public health and economics all over the world. Different populations...
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SubjectTerms COVID-19
Humans
NF-kappa B - metabolism
Peptidyl-Dipeptidase A - metabolism
Review
SARS-CoV-2
Signal Transduction
Title The role of SARS-CoV-2-mediated NF-κB activation in COVID-19 patients
URI https://www.ncbi.nlm.nih.gov/pubmed/37872376
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https://pubmed.ncbi.nlm.nih.gov/PMC10838770
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