Galectin-3 Mediates Vascular Dysfunction in Obesity by Regulating NADPH Oxidase 1

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 43; no. 10; pp. e381 - e395
• Main Authors: Padgett, Caleb A, Bátori, Róbert K, Speese, Andrew C, Rosewater, Cody L, Bush, Weston B, Derella, Cassandra C, Haigh, Stephen B, Sellers, Hunter G, Corley, Zachary L, West, Madison A, Mintz, James D, Ange, Brittany B, Harris, Ryan A, Brands, Michael W, Fulton, David J R, Stepp, David W
• Format: Journal Article
• Language: English
• Published: United States 01.10.2023
• Subjects: Animals; Cardiovascular Diseases; Endothelial Cells - metabolism; Endothelium, Vascular - metabolism; Galectin 3 - genetics; Galectin 3 - metabolism; Humans; Hyperglycemia - metabolism; Hypertension; Mice; Mice, Knockout; Mice, Obese; NADPH Oxidase 1 - metabolism; NADPH Oxidases - metabolism; Obesity - complications; Obesity - genetics; Obesity - metabolism; Oxidative Stress; metabolic syndrome; NADPH oxidases; insulin; galectin-3; obesity

Obesity is associated with increased risk of cardiovascular disease, but underlying mechanisms remain elusive. Metabolic dysfunction, especially hyperglycemia, is thought to be a major contributor, but how glucose impacts vascular function is unclear. GAL3 (galectin-3) is a sugar-binding lectin upre...