Podocyte-Specific Loss of Krüppel-Like Factor 6 Increases Mitochondrial Injury in Diabetic Kidney Disease

• Published in: Diabetes (New York, N.Y.) Vol. 67; no. 11; pp. 2420 - 2433
• Main Authors: Horne, Sylvia J., Vasquez, Jessica M., Guo, Yiqing, Ly, Victoria, Piret, Sian E., Leonardo, Alexandra R., Ling, Jason, Revelo, Monica P., Bogenhagen, Daniel, Yang, Vincent W., He, John C., Mallipattu, Sandeep K.
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.11.2018
• Subjects: Animal models; Animals; Apoptosis; Apoptosis - physiology; Biopsy; Blood Pressure - physiology; Cells; Complications; Cytochrome-c oxidase; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - pathology; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - pathology; Diabetic nephropathy; Glomerular Filtration Rate - physiology; Humans; Kidney - metabolism; Kidney - pathology; Kidney diseases; Kidneys; Kruppel-Like Factor 6 - genetics; Kruppel-Like Factor 6 - metabolism; Mice; Mitochondria; Mitochondria - metabolism; Mitochondria - pathology; Podocytes - metabolism; Podocytes - pathology; Proteinuria - metabolism; Proteinuria - pathology; Streptozocin; Transcription; Zinc finger proteins

Mitochondrial injury is uniformly observed in several murine models as well as in individuals with diabetic kidney disease (DKD). Although emerging evidence has highlighted the role of key transcriptional regulators in mitochondrial biogenesis, little is known about the regulation of mitochondrial c...