Chemotherapy-induced gut microbiome disruption, inflammation, and cognitive decline in female patients with breast cancer

• Published in: Brain, behavior, and immunity Vol. 120; pp. 208 - 220
• Main Authors: Otto-Dobos, L.D., Grant, C.V., Lahoud, A.A., Wilcox, O.R., Strehle, L.D., Loman, B.R., Adarkwah Yiadom, S., Seng, M.M., Halloy, N.R., Russart, K.L.G., Carpenter, K.M., Dawson, E., Sardesai, S.D., Williams, N.O., Gatti-Mays, M.E., Stover, D.G., Sudheendra, P.K., Wesolowski, R., Kiecolt-Glaser, J.K., Bailey, M.T., Andridge, R.R., Pyter, L.M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.08.2024
• Subjects: Adult; Aged; Antineoplastic Agents - adverse effects; Breast Neoplasms - drug therapy; Cognition - drug effects; Cognitive Dysfunction - chemically induced; Cognitive Dysfunction - microbiology; Cognitive impairment; Cytokines; Cytokines - blood; Cytokines - metabolism; Differential abundance analysis; Feces - microbiology; Female; Gastrointestinal Microbiome - drug effects; Humans; Inflammation - microbiology; Interleukin-6 - blood; Interleukin-6 - metabolism; Longitudinal Studies; Microbial diversity; Middle Aged; Objective cognition; Subjective cognition; Tumor Necrosis Factor-alpha - blood; Tumor Necrosis Factor-alpha - metabolism; Microbial diversity; Differential abundance analysis; Subjective cognition; Cytokines; Objective cognition; Cognitive impairment

•Chemotherapy induces microbiome disruption, inflammation, and cognitive decline.•The resulting microbiome disruption relates to cognitive decline and inflammation.•Those cognitively impaired have unique chemotherapy-induced microbiome alterations. Chemotherapy is notorious for causing behavioral si...