Near-infrared dye IRDye800CW-NHS coupled to Trastuzumab for near-infrared II fluorescence imaging in tumor xenograft models of HER-2-positive breast cancer

• Published in: Journal of materials chemistry. B, Materials for biology and medicine Vol. 11; no. 44; pp. 1738 - 1746
• Main Authors: Xiao, Junhui, Qiu, Siqi, Ma, Qiufeng, Bai, Silan, Guo, Xinrong, Wang, Lishi
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 15.11.2023
• Subjects: Animal models; Animals; Antibodies; Breast cancer; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Cell Line, Tumor; Coupling; Dyes; ErbB-2 protein; Female; Fluorescence; Fluorescent dyes; Fluorescent Dyes - chemistry; Fluorescent indicators; Heterografts; Histopathology; Humans; I.R. radiation; Infrared imaging; Kidneys; Medical imaging; Mice; Near infrared radiation; Optical Imaging - methods; Optical properties; Probes; State Medicine; Trastuzumab; Tumors; Xenografts; Xenotransplantation

Near-infrared II fluorescent probes targeting tumors for diagnostic purposes have received much attention in recent years. In this study, a fluorescent probe for the NIR-II was constructed by using IRDye800CW-NHS fluorescent dye with Trastuzumab, which was investigated for its ability to target HER-...