SNCA variants and alpha-synuclein level in CD45+ blood cells in Parkinson’s disease
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder. Impaired metabolism of alpha-synuclein (SNCA) and its aggregation are implicated in PD pathogenesis. SNCA has been identified as a highly significant genetic risk loci associated with the sporadic form of PD in acr...
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| Published in | Journal of the neurological sciences Vol. 395; pp. 135 - 140 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
15.12.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-510X 1878-5883 1878-5883 |
| DOI | 10.1016/j.jns.2018.10.002 |
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| Abstract | Parkinson's disease (PD) is the second most frequent neurodegenerative disorder. Impaired metabolism of alpha-synuclein (SNCA) and its aggregation are implicated in PD pathogenesis. SNCA has been identified as a highly significant genetic risk loci associated with the sporadic form of PD in across populations in GWAS and replicative studies.
In this study we conducted a genetic analysis of five SNCA single nucleotide polymorphisms (SNPs) (rs356219, rs2619364, rs11931074, rs2583988, rs356168) in 458 PD patients and 353 from North-West region of Russia. We also assessed an association of studied SNPs with alpha-synuclein levels in homogeneous cell fraction of CD45+ blood cells in PD patients and controls. An association with PD was shown for SNPs rs356219, rs11931074, rs356168. After correction for covariates the significant association with the disease only for rs11931074 and rs356168 was shown. Alpha-synuclein level in peripheral blood CD45+ cells was significantly increased in PD patients compared to control subjects (р = 0.02). The effect of SNCA rs356219 and rs356168 on CD45+ alpha-synuclein level in PD patients and control groups was shown. At the same tame the increase of CD45+ alpha-synuclein level in PD patients was revealed only in risk allele carriers as for rs356219 and rs356168 SNPs. Therefore, our study was the first that demonstrated the increased level of alpha-synuclein in CD45+ blood cells in PD patients and showed that it could be influenced by SNCA rs356168 and rs356219. In conclusion we confirmed the significance of the SNCA locus in the PD development.
•SNCA SNPs rs356219, rs2619364, rs11931074, rs356168 are associated with PD.•CD45+ alpha-synuclein is increased in sporadic PD patients.•CD45+ alpha-synuclein in PD patients could be influenced by SNCA rs356168 and rs356219. |
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| AbstractList | Parkinson's disease (PD) is the second most frequent neurodegenerative disorder. Impaired metabolism of alpha-synuclein (SNCA) and its aggregation are implicated in PD pathogenesis. SNCA has been identified as a highly significant genetic risk loci associated with the sporadic form of PD in across populations in GWAS and replicative studies.
In this study we conducted a genetic analysis of five SNCA single nucleotide polymorphisms (SNPs) (rs356219, rs2619364, rs11931074, rs2583988, rs356168) in 458 PD patients and 353 from North-West region of Russia. We also assessed an association of studied SNPs with alpha-synuclein levels in homogeneous cell fraction of CD45+ blood cells in PD patients and controls. An association with PD was shown for SNPs rs356219, rs11931074, rs356168. After correction for covariates the significant association with the disease only for rs11931074 and rs356168 was shown. Alpha-synuclein level in peripheral blood CD45+ cells was significantly increased in PD patients compared to control subjects (р = 0.02). The effect of SNCA rs356219 and rs356168 on CD45+ alpha-synuclein level in PD patients and control groups was shown. At the same tame the increase of CD45+ alpha-synuclein level in PD patients was revealed only in risk allele carriers as for rs356219 and rs356168 SNPs. Therefore, our study was the first that demonstrated the increased level of alpha-synuclein in CD45+ blood cells in PD patients and showed that it could be influenced by SNCA rs356168 and rs356219. In conclusion we confirmed the significance of the SNCA locus in the PD development.
•SNCA SNPs rs356219, rs2619364, rs11931074, rs356168 are associated with PD.•CD45+ alpha-synuclein is increased in sporadic PD patients.•CD45+ alpha-synuclein in PD patients could be influenced by SNCA rs356168 and rs356219. Parkinson's disease (PD) is the second most frequent neurodegenerative disorder. Impaired metabolism of alpha-synuclein (SNCA) and its aggregation are implicated in PD pathogenesis. SNCA has been identified as a highly significant genetic risk loci associated with the sporadic form of PD in across populations in GWAS and replicative studies. In this study we conducted a genetic analysis of five SNCA single nucleotide polymorphisms (SNPs) (rs356219, rs2619364, rs11931074, rs2583988, rs356168) in 458 PD patients and 353 from North-West region of Russia. We also assessed an association of studied SNPs with alpha-synuclein levels in homogeneous cell fraction of CD45+ blood cells in PD patients and controls. An association with PD was shown for SNPs rs356219, rs11931074, rs356168. After correction for covariates the significant association with the disease only for rs11931074 and rs356168 was shown. Alpha-synuclein level in peripheral blood CD45+ cells was significantly increased in PD patients compared to control subjects (р = 0.02). The effect of SNCA rs356219 and rs356168 on CD45+ alpha-synuclein level in PD patients and control groups was shown. At the same tame the increase of CD45+ alpha-synuclein level in PD patients was revealed only in risk allele carriers as for rs356219 and rs356168 SNPs. Therefore, our study was the first that demonstrated the increased level of alpha-synuclein in CD45+ blood cells in PD patients and showed that it could be influenced by SNCA rs356168 and rs356219. In conclusion we confirmed the significance of the SNCA locus in the PD development. Parkinson's disease (PD) is the second most frequent neurodegenerative disorder. Impaired metabolism of alpha-synuclein (SNCA) and its aggregation are implicated in PD pathogenesis. SNCA has been identified as a highly significant genetic risk loci associated with the sporadic form of PD in across populations in GWAS and replicative studies. In this study we conducted a genetic analysis of five SNCA single nucleotide polymorphisms (SNPs) (rs356219, rs2619364, rs11931074, rs2583988, rs356168) in 458 PD patients and 353 from North-West region of Russia. We also assessed an association of studied SNPs with alpha-synuclein levels in homogeneous cell fraction of CD45+ blood cells in PD patients and controls. An association with PD was shown for SNPs rs356219, rs11931074, rs356168. After correction for covariates the significant association with the disease only for rs11931074 and rs356168 was shown. Alpha-synuclein level in peripheral blood CD45+ cells was significantly increased in PD patients compared to control subjects (р = 0.02). The effect of SNCA rs356219 and rs356168 on CD45+ alpha-synuclein level in PD patients and control groups was shown. At the same tame the increase of CD45+ alpha-synuclein level in PD patients was revealed only in risk allele carriers as for rs356219 and rs356168 SNPs. Therefore, our study was the first that demonstrated the increased level of alpha-synuclein in CD45+ blood cells in PD patients and showed that it could be influenced by SNCA rs356168 and rs356219. In conclusion we confirmed the significance of the SNCA locus in the PD development.Parkinson's disease (PD) is the second most frequent neurodegenerative disorder. Impaired metabolism of alpha-synuclein (SNCA) and its aggregation are implicated in PD pathogenesis. SNCA has been identified as a highly significant genetic risk loci associated with the sporadic form of PD in across populations in GWAS and replicative studies. In this study we conducted a genetic analysis of five SNCA single nucleotide polymorphisms (SNPs) (rs356219, rs2619364, rs11931074, rs2583988, rs356168) in 458 PD patients and 353 from North-West region of Russia. We also assessed an association of studied SNPs with alpha-synuclein levels in homogeneous cell fraction of CD45+ blood cells in PD patients and controls. An association with PD was shown for SNPs rs356219, rs11931074, rs356168. After correction for covariates the significant association with the disease only for rs11931074 and rs356168 was shown. Alpha-synuclein level in peripheral blood CD45+ cells was significantly increased in PD patients compared to control subjects (р = 0.02). The effect of SNCA rs356219 and rs356168 on CD45+ alpha-synuclein level in PD patients and control groups was shown. At the same tame the increase of CD45+ alpha-synuclein level in PD patients was revealed only in risk allele carriers as for rs356219 and rs356168 SNPs. Therefore, our study was the first that demonstrated the increased level of alpha-synuclein in CD45+ blood cells in PD patients and showed that it could be influenced by SNCA rs356168 and rs356219. In conclusion we confirmed the significance of the SNCA locus in the PD development. |
| Author | Emelyanov, A. Kulabukhova, D. Verbitskaya, E. Kopytova, A. Ilves, A. Yakimovskii, A. Andoskin, P. Prakhova, L. Nikolaev, M. Timofeeva, A. Garaeva, L. Vlasova, I. Pchelina, S. Senkevich, K. Milyukhina, I. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30316070$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.neulet.2010.06.009 10.1038/ncomms2032 10.1016/j.neulet.2009.06.034 10.1002/ana.22321 10.1096/fj.04-1917fje 10.1371/journal.pone.0006906 10.1212/01.WNL.0000127517.33208.F4 10.1002/mds.26319 10.1002/ajmg.b.32288 10.1038/ng.3043 10.1111/j.1600-0404.2008.01019.x 10.1016/j.mcp.2016.11.001 10.1016/j.mad.2007.04.002 10.1212/01.wnl.0000275524.15125.f4 10.1016/j.parkreldis.2013.06.003 10.1159/000112832 10.1038/42166 10.1016/j.neurobiolaging.2008.06.010 10.1136/jnnp.55.3.181 10.1016/S1353-8020(13)70025-7 10.1096/fj.07-9348com 10.2174/157015911795596612 10.1038/ng.487 10.1038/jhg.2013.90 10.1111/ane.12247 10.1001/archneurol.2010.279 10.1007/s10517-011-1221-3 10.1002/ana.20438 10.1038/nature17939 10.1007/s00415-011-6209-4 |
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| Keywords | GWAS OR Parkinson's disease CI RBCs SD CD45+ cells UTR PD SNP CSF HWE L-DOPA SNCA, alpha-synuclein Genetic association SNCA |
| Language | English |
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| References | Malek, Swallow, Grosset, Anichtchik, Spillantini, Grosset (bb0020) 2014; 130 Hu, Tang, Guo, Wu, Sun, Shi, Hu, Wang, Wang, Tan, Shen, Yan, Zhang (bb0155) 2012; 259 Sotiriou, Gibney, Baxevanis, Nussbaum (bb0165) 2009; 461 Hughes, Daniel, Kilford, Lees (bb0070) 1992; 55 Mizuta, Takafuji, Ando, Satake, Kanagawa, Kobayashi, Nagamori, Shinohara, Ito, Yamamoto, Hattori, Murata, Kanai, Murayama, Nakagawa, Toda (bb0135) 2013; 58 Mueller, Fuchs, Hofer, Zimprich, Lichtner, Illig, Berg, Wüllner, Meitinger, Gasser (bb0050) 2005; 57 Myhre, Toft, Kachergus, Hulihan, Aasly, Klungland, Farrer (bb0040) 2008; 118 Outeiro, Klucken, Bercury, Tetzlaff, Putcha, Oliveira, Quintas, McLean, Hyman (bb0090) 2009; 4 R. Buttarelli, Fanciulli, Pellicano, E. Pontieri (bb0125) 2011; 9 Simón-Sánchez, Schulte, Bras, Sharma, Gibbs, Berg, Paisan-Ruiz, Lichtner, Scholz, Hernandez, Krüger, Federoff, Klein, Goate, Perlmutter, Bonin, Nalls, Illig, Gieger, Houlden, Steffens, Okun, Racette, Cookson, Foote, Fernandez, Traynor, Schreiber, Arepalli, Zonozi, Gwinn, van der Brug, Lopez, Chanock, Schatzkin, Park, Hollenbeck, Gao, Huang, Wood, Lorenz, Deuschl, Chen, Riess, Hardy, Singleton, Gasser (bb0035) 2009; 41 Emelyanov, Andoskin, Miliukhina, Timofeeva, Yakimovskii, Senkevich, Nikolaev, Pchelina (bb0130) 2016; 58 Miller, Hague, Clarimon, Baptista, Gwinn-Hardy, Cookson, Singleton (bb0015) 2004; 62 Benjamini, Hochberg (bb0075) 1985; 85 Fuchs, Tichopad, Golub, Munz, Schweitzer, Wolf, Berg, Mueller, Gasser (bb0105) 2007; 22 Schmitt, Kaut, Khazneh, Deboni, Ahmad, Berg, Klein, Fröhlich, Wüllner (bb0095) 2015; 30 Shi, Zabetian, Hancock, Ginghina, Hong, Yearout, Chung, Quinn, Peskind, Galasko, Jankovic, Leverenz, Zhang (bb0030) 2010; 480 Ross, Gosal, Stone, Lincoln, Heckman, Irvine, Johnston, Gibson, Farrer, Lynch (bb0045) 2007; 128 Soldner, Stelzer, Shivalila, Abraham, Latourelle, Barrasa, Goldmann, Myers, Young, Jaenisch (bb0145) 2016; 533 Barbour, Kling, Anderson, Banducci, Cole, Diep, Fox, Goldstein, Soriano, Seubert, Chilcote (bb0120) 2008; 5 Han, Liu, Mi, Zhao, Liu, Tian (bb0080) 2015; 168 Brighina, Prigione, Begni, Galbussera, Andreoni, Piolti, Ferrarese (bb0110) 2010; 31 Mata, Shi, Agarwal, Chung, Edwards, Factor, Galasko, Ginghina, Griffith, Higgins, Kay, Kim, Leverenz, Quinn, Roberts, Samii, Snapinn, Tsuang, Yearout, Zhang, Payami, Zabetian (bb0060) 2010; 67 Nalls, Pankratz, Lill, Do, Hernandez, Saad, Destefano, Kara, Bras, Sharma, Schulte, Keller, Arepalli, Letson, Edsall, Stefansson, Liu, Pliner, Lee, Cheng, Ikram, Ioannidis, Hadjigeorgiou, Bis, Martinez, Perlmutter, Goate, Marder, Fiske, Sutherland, Xiromerisiou, Myers, Clark, Stefansson, Hardy, Heutink, Chen, Wood, Houlden, Payami, Brice, Scott, Gasser, Bertram, Eriksson, Foroud, Singleton (bb0085) 2014; 46 Elbaz, Ross, Ioannidis, Soto-Ortolaza, Moisan, Aasly, Annesi, Bozi, Brighina, Chartier-Harlin, Destée, Ferrarese, Ferraris, Gibson, Gispert, Hadjigeorgiou, Jasinska-Myga, Klein, Krüger, Lambert, Lohmann, van de Loo, Loriot, Lynch, Mellick, Mutez, Nilsson, Opala, Puschmann, Quattrone, Sharma, Silburn, Stefanis, Uitti, Valente, Vilariño-Güell, Wirdefeldt, Wszolek, Xiromerisiou, Maraganore, Farrer (bb0160) 2011; 69 Lill (bb0005) 2016; 30 Spillantini, Schmidt, Lee, Trojanowski, Jakes, Goedert (bb0010) 1997; 388 Winkler, Hagenah, Lincoln, Heckman, Haugarvoll, Lohmann-Hedrich, Kostic, Farrer, Klein (bb0055) 2007; 69 Kang, Chen, Yang, Zhang, Zhang, Wang, Dong, Zhao, Chen, Quinn, Zhang, Chen, Liu (bb0150) 2016; 6 Kim, Jeon, Heo, Im, Ahn, Seo, Kim, Park, Choi, Cho, Lee, Suh (bb0100) 2004; 18 Chahine, Stern, Chen-Plotkin (bb0025) 2014; 20 Pchelina, Emelyanov, Yakimovskii, Miller, Shabalina, Drozdova, Schwarzman (bb0115) 2011; 150 Rhinn, Qiang, Yamashita, Rhee, Zolin, Vanti, Abeliovich (bb0140) 2012; 3 Emelyanov, Andoskin, Yakimovskii, Usenko, Nuzhnyi, Nikolaev, Pchelina (bb0065) 2013; 19 Brighina (10.1016/j.jns.2018.10.002_bb0110) 2010; 31 Kang (10.1016/j.jns.2018.10.002_bb0150) 2016; 6 Pchelina (10.1016/j.jns.2018.10.002_bb0115) 2011; 150 Mata (10.1016/j.jns.2018.10.002_bb0060) 2010; 67 R. Buttarelli (10.1016/j.jns.2018.10.002_bb0125) 2011; 9 Hughes (10.1016/j.jns.2018.10.002_bb0070) 1992; 55 Simón-Sánchez (10.1016/j.jns.2018.10.002_bb0035) 2009; 41 Emelyanov (10.1016/j.jns.2018.10.002_bb0065) 2013; 19 Schmitt (10.1016/j.jns.2018.10.002_bb0095) 2015; 30 Emelyanov (10.1016/j.jns.2018.10.002_bb0130) 2016; 58 Rhinn (10.1016/j.jns.2018.10.002_bb0140) 2012; 3 Barbour (10.1016/j.jns.2018.10.002_bb0120) 2008; 5 Spillantini (10.1016/j.jns.2018.10.002_bb0010) 1997; 388 Miller (10.1016/j.jns.2018.10.002_bb0015) 2004; 62 Myhre (10.1016/j.jns.2018.10.002_bb0040) 2008; 118 Mizuta (10.1016/j.jns.2018.10.002_bb0135) 2013; 58 Sotiriou (10.1016/j.jns.2018.10.002_bb0165) 2009; 461 Nalls (10.1016/j.jns.2018.10.002_bb0085) 2014; 46 Elbaz (10.1016/j.jns.2018.10.002_bb0160) 2011; 69 Chahine (10.1016/j.jns.2018.10.002_bb0025) 2014; 20 Han (10.1016/j.jns.2018.10.002_bb0080) 2015; 168 Shi (10.1016/j.jns.2018.10.002_bb0030) 2010; 480 Lill (10.1016/j.jns.2018.10.002_bb0005) 2016; 30 Ross (10.1016/j.jns.2018.10.002_bb0045) 2007; 128 Mueller (10.1016/j.jns.2018.10.002_bb0050) 2005; 57 Hu (10.1016/j.jns.2018.10.002_bb0155) 2012; 259 Winkler (10.1016/j.jns.2018.10.002_bb0055) 2007; 69 Malek (10.1016/j.jns.2018.10.002_bb0020) 2014; 130 Benjamini (10.1016/j.jns.2018.10.002_bb0075) 1985; 85 Outeiro (10.1016/j.jns.2018.10.002_bb0090) 2009; 4 Fuchs (10.1016/j.jns.2018.10.002_bb0105) 2007; 22 Kim (10.1016/j.jns.2018.10.002_bb0100) 2004; 18 Soldner (10.1016/j.jns.2018.10.002_bb0145) 2016; 533 |
| References_xml | – volume: 62 start-page: 1835 year: 2004 end-page: 1838 ident: bb0015 article-title: Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication publication-title: Neurology – volume: 58 start-page: 99 year: 2016 end-page: 104 ident: bb0130 article-title: rs356219 and rs356165 variants are associated with Parkinson's disease and increased alpha-synuclein gene expression in the CD45(+)-blood cells publication-title: Cell Tissue Biol. – volume: 533 start-page: 95 year: 2016 end-page: 99 ident: bb0145 article-title: Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression publication-title: Nature – volume: 67 start-page: 1350 year: 2010 end-page: 1356 ident: bb0060 article-title: SNCA variant associated with Parkinson disease and plasma α-synuclein level publication-title: Arch. Neurol. – volume: 128 start-page: 378 year: 2007 end-page: 382 ident: bb0045 article-title: Familial genes in sporadic disease: Common variants of α-synuclein gene associated with Parkinson's disease publication-title: Mech. Ageing Dev. – volume: 30 start-page: 386 year: 2016 end-page: 396 ident: bb0005 article-title: Genetics of Parkinson's disease publication-title: Mol. Cell. Probes – volume: 388 start-page: 839 year: 1997 end-page: 840 ident: bb0010 article-title: α-Synuclein in Lewy bodies publication-title: Nature – volume: 480 start-page: 78 year: 2010 end-page: 82 ident: bb0030 article-title: Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease publication-title: Neurosci. Lett. – volume: 22 start-page: 1327 year: 2007 end-page: 1334 ident: bb0105 article-title: Genetic variability in the SNCA gene influences -synuclein levels in the blood and brain publication-title: FASEB J. – volume: 46 start-page: 989 year: 2014 end-page: 993 ident: bb0085 article-title: Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease publication-title: Nat. Genet. – volume: 57 start-page: 535 year: 2005 end-page: 541 ident: bb0050 article-title: Multiple regions of α-synuclein are associated with Parkinson's disease publication-title: Ann. Neurol. – volume: 118 start-page: 320 year: 2008 end-page: 327 ident: bb0040 article-title: Multiple alpha-synuclein gene polymorphisms are associated with Parkinson's disease in a Norwegian population publication-title: Acta Neurol. Scand. – volume: 6 year: 2016 ident: bb0150 article-title: Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson's disease patients publication-title: Sci. Rep. – volume: 150 start-page: 679 year: 2011 end-page: 681 ident: bb0115 article-title: Reduced content of α-synuclein in peripheral blood leukocytes of patients with LRRK2-associated Parkinson's disease publication-title: Bull. Exp. Biol. Med. – volume: 20 start-page: 99 year: 2014 end-page: 103 ident: bb0025 article-title: Blood-based biomarkers for Parkinson's disease publication-title: Parkinsonism Relat. Disord. – volume: 18 start-page: 1615 year: 2004 end-page: 1617 ident: bb0100 article-title: Alpha-synuclein induces apoptosis by altered expression in human peripheral lymphocytes in Parkinson's disease publication-title: FASEB J. – volume: 3 start-page: 1084 year: 2012 ident: bb0140 article-title: Alternative α-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology publication-title: Nat. Commun. – volume: 130 start-page: 59 year: 2014 end-page: 72 ident: bb0020 article-title: Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review publication-title: Acta Neurol. Scand. – volume: 9 start-page: 278 year: 2011 end-page: 288 ident: bb0125 article-title: The dopaminergic system in peripheral blood lymphocytes: from physiology to pharmacology and potential applications to neuropsychiatric disorders publication-title: Curr. Neuropharmacol. – volume: 85 start-page: 289 year: 1985 end-page: 300 ident: bb0075 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J. Royal. Stat. Soc. B. – volume: 58 start-page: 711 year: 2013 end-page: 719 ident: bb0135 article-title: YY1 binds to α-synuclein 3′-flanking region SNP and stimulates antisense noncoding RNA expression publication-title: J. Hum. Genet. – volume: 168 start-page: 123 year: 2015 end-page: 134 ident: bb0080 article-title: Alpha-synuclein (SNCA) polymorphisms and susceptibility to Parkinson's disease: a meta-analysis publication-title: Am. J. Med. Genet. B Neuropsychiatr. Genet. – volume: 5 start-page: 55 year: 2008 end-page: 59 ident: bb0120 article-title: Red Blood Cells are the Major source of Alpha-Synuclein in Blood publication-title: Neurodegener. Dis. – volume: 259 start-page: 497 year: 2012 end-page: 504 ident: bb0155 article-title: Variant in the 3′ region of SNCA associated with Parkinson's disease and serum α-synuclein levels publication-title: J. Neurol. – volume: 69 start-page: 778 year: 2011 end-page: 792 ident: bb0160 article-title: Genetic epidemiology of Parkinson's disease (GEO-PD) Consortium, independent and joint effects of the MAPT and SNCA genes in Parkinson disease publication-title: Ann. Neurol. – volume: 41 start-page: 1308 year: 2009 end-page: 1312 ident: bb0035 article-title: Genome-wide association study reveals genetic risk underlying Parkinson's disease publication-title: Nat. Genet. – volume: 69 start-page: 1745 year: 2007 end-page: 1750 ident: bb0055 article-title: Alpha-Synuclein and Parkinson disease susceptibility publication-title: Neurology – volume: 55 start-page: 181 year: 1992 end-page: 184 ident: bb0070 article-title: Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases publication-title: J. Neurol. Neurosurg. Psychiatry – volume: 30 start-page: 1794 year: 2015 end-page: 1801 ident: bb0095 article-title: L-dopa increases α -synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro publication-title: Mov. Disord. – volume: 461 start-page: 196 year: 2009 end-page: 201 ident: bb0165 article-title: A single nucleotide polymorphism in the 3′UTR of the SNCA gene encoding alpha-synuclein is a new potential susceptibility locus for Parkinson disease publication-title: Neurosci. Lett. – volume: 31 start-page: 884 year: 2010 end-page: 885 ident: bb0110 article-title: Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease publication-title: Neurobiol. Aging – volume: 19 start-page: 1064 year: 2013 end-page: 1065 ident: bb0065 article-title: SNCA, LRRK2, MAPT polymorphisms and Parkinson's disease in Russia publication-title: Parkinsonism Relat. Disord. – volume: 4 year: 2009 ident: bb0090 article-title: Dopamine-Induced Conformational changes in Alpha-Synuclein publication-title: PLoS One – volume: 480 start-page: 78 year: 2010 ident: 10.1016/j.jns.2018.10.002_bb0030 article-title: Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2010.06.009 – volume: 3 start-page: 1084 year: 2012 ident: 10.1016/j.jns.2018.10.002_bb0140 article-title: Alternative α-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology publication-title: Nat. Commun. doi: 10.1038/ncomms2032 – volume: 85 start-page: 289 year: 1985 ident: 10.1016/j.jns.2018.10.002_bb0075 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J. Royal. Stat. Soc. B. – volume: 6 year: 2016 ident: 10.1016/j.jns.2018.10.002_bb0150 article-title: Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson's disease patients publication-title: Sci. Rep. – volume: 461 start-page: 196 year: 2009 ident: 10.1016/j.jns.2018.10.002_bb0165 article-title: A single nucleotide polymorphism in the 3′UTR of the SNCA gene encoding alpha-synuclein is a new potential susceptibility locus for Parkinson disease publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2009.06.034 – volume: 69 start-page: 778 year: 2011 ident: 10.1016/j.jns.2018.10.002_bb0160 article-title: Genetic epidemiology of Parkinson's disease (GEO-PD) Consortium, independent and joint effects of the MAPT and SNCA genes in Parkinson disease publication-title: Ann. Neurol. doi: 10.1002/ana.22321 – volume: 18 start-page: 1615 year: 2004 ident: 10.1016/j.jns.2018.10.002_bb0100 article-title: Alpha-synuclein induces apoptosis by altered expression in human peripheral lymphocytes in Parkinson's disease publication-title: FASEB J. doi: 10.1096/fj.04-1917fje – volume: 4 year: 2009 ident: 10.1016/j.jns.2018.10.002_bb0090 article-title: Dopamine-Induced Conformational changes in Alpha-Synuclein publication-title: PLoS One doi: 10.1371/journal.pone.0006906 – volume: 62 start-page: 1835 year: 2004 ident: 10.1016/j.jns.2018.10.002_bb0015 article-title: Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication publication-title: Neurology doi: 10.1212/01.WNL.0000127517.33208.F4 – volume: 30 start-page: 1794 year: 2015 ident: 10.1016/j.jns.2018.10.002_bb0095 article-title: L-dopa increases α -synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro publication-title: Mov. Disord. doi: 10.1002/mds.26319 – volume: 168 start-page: 123 year: 2015 ident: 10.1016/j.jns.2018.10.002_bb0080 article-title: Alpha-synuclein (SNCA) polymorphisms and susceptibility to Parkinson's disease: a meta-analysis publication-title: Am. J. Med. Genet. B Neuropsychiatr. Genet. doi: 10.1002/ajmg.b.32288 – volume: 46 start-page: 989 year: 2014 ident: 10.1016/j.jns.2018.10.002_bb0085 article-title: Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease publication-title: Nat. Genet. doi: 10.1038/ng.3043 – volume: 118 start-page: 320 year: 2008 ident: 10.1016/j.jns.2018.10.002_bb0040 article-title: Multiple alpha-synuclein gene polymorphisms are associated with Parkinson's disease in a Norwegian population publication-title: Acta Neurol. Scand. doi: 10.1111/j.1600-0404.2008.01019.x – volume: 30 start-page: 386 year: 2016 ident: 10.1016/j.jns.2018.10.002_bb0005 article-title: Genetics of Parkinson's disease publication-title: Mol. Cell. Probes doi: 10.1016/j.mcp.2016.11.001 – volume: 128 start-page: 378 year: 2007 ident: 10.1016/j.jns.2018.10.002_bb0045 article-title: Familial genes in sporadic disease: Common variants of α-synuclein gene associated with Parkinson's disease publication-title: Mech. Ageing Dev. doi: 10.1016/j.mad.2007.04.002 – volume: 69 start-page: 1745 year: 2007 ident: 10.1016/j.jns.2018.10.002_bb0055 article-title: Alpha-Synuclein and Parkinson disease susceptibility publication-title: Neurology doi: 10.1212/01.wnl.0000275524.15125.f4 – volume: 19 start-page: 1064 year: 2013 ident: 10.1016/j.jns.2018.10.002_bb0065 article-title: SNCA, LRRK2, MAPT polymorphisms and Parkinson's disease in Russia publication-title: Parkinsonism Relat. Disord. doi: 10.1016/j.parkreldis.2013.06.003 – volume: 5 start-page: 55 year: 2008 ident: 10.1016/j.jns.2018.10.002_bb0120 article-title: Red Blood Cells are the Major source of Alpha-Synuclein in Blood publication-title: Neurodegener. Dis. doi: 10.1159/000112832 – volume: 58 start-page: 99 year: 2016 ident: 10.1016/j.jns.2018.10.002_bb0130 article-title: SNCA rs356219 and rs356165 variants are associated with Parkinson's disease and increased alpha-synuclein gene expression in the CD45(+)-blood cells publication-title: Cell Tissue Biol. – volume: 388 start-page: 839 year: 1997 ident: 10.1016/j.jns.2018.10.002_bb0010 article-title: α-Synuclein in Lewy bodies publication-title: Nature doi: 10.1038/42166 – volume: 31 start-page: 884 year: 2010 ident: 10.1016/j.jns.2018.10.002_bb0110 article-title: Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2008.06.010 – volume: 55 start-page: 181 year: 1992 ident: 10.1016/j.jns.2018.10.002_bb0070 article-title: Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp.55.3.181 – volume: 20 start-page: 99 year: 2014 ident: 10.1016/j.jns.2018.10.002_bb0025 article-title: Blood-based biomarkers for Parkinson's disease publication-title: Parkinsonism Relat. Disord. doi: 10.1016/S1353-8020(13)70025-7 – volume: 22 start-page: 1327 year: 2007 ident: 10.1016/j.jns.2018.10.002_bb0105 article-title: Genetic variability in the SNCA gene influences -synuclein levels in the blood and brain publication-title: FASEB J. doi: 10.1096/fj.07-9348com – volume: 9 start-page: 278 year: 2011 ident: 10.1016/j.jns.2018.10.002_bb0125 article-title: The dopaminergic system in peripheral blood lymphocytes: from physiology to pharmacology and potential applications to neuropsychiatric disorders publication-title: Curr. Neuropharmacol. doi: 10.2174/157015911795596612 – volume: 41 start-page: 1308 year: 2009 ident: 10.1016/j.jns.2018.10.002_bb0035 article-title: Genome-wide association study reveals genetic risk underlying Parkinson's disease publication-title: Nat. Genet. doi: 10.1038/ng.487 – volume: 58 start-page: 711 year: 2013 ident: 10.1016/j.jns.2018.10.002_bb0135 article-title: YY1 binds to α-synuclein 3′-flanking region SNP and stimulates antisense noncoding RNA expression publication-title: J. Hum. Genet. doi: 10.1038/jhg.2013.90 – volume: 130 start-page: 59 year: 2014 ident: 10.1016/j.jns.2018.10.002_bb0020 article-title: Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review publication-title: Acta Neurol. Scand. doi: 10.1111/ane.12247 – volume: 67 start-page: 1350 year: 2010 ident: 10.1016/j.jns.2018.10.002_bb0060 article-title: SNCA variant associated with Parkinson disease and plasma α-synuclein level publication-title: Arch. Neurol. doi: 10.1001/archneurol.2010.279 – volume: 150 start-page: 679 year: 2011 ident: 10.1016/j.jns.2018.10.002_bb0115 article-title: Reduced content of α-synuclein in peripheral blood leukocytes of patients with LRRK2-associated Parkinson's disease publication-title: Bull. Exp. Biol. Med. doi: 10.1007/s10517-011-1221-3 – volume: 57 start-page: 535 year: 2005 ident: 10.1016/j.jns.2018.10.002_bb0050 article-title: Multiple regions of α-synuclein are associated with Parkinson's disease publication-title: Ann. Neurol. doi: 10.1002/ana.20438 – volume: 533 start-page: 95 year: 2016 ident: 10.1016/j.jns.2018.10.002_bb0145 article-title: Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression publication-title: Nature doi: 10.1038/nature17939 – volume: 259 start-page: 497 year: 2012 ident: 10.1016/j.jns.2018.10.002_bb0155 article-title: Variant in the 3′ region of SNCA associated with Parkinson's disease and serum α-synuclein levels publication-title: J. Neurol. doi: 10.1007/s00415-011-6209-4 |
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