Leach-proof magnetic thrombolytic nanoparticles and coatings of enhanced activity

• Published in: Scientific reports Vol. 6; no. 1; p. 28119
• Main Authors: Drozdov, Andrey S, Vinogradov, Vasiliy V, Dudanov, Ivan P, Vinogradov, Vladimir V
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 20.06.2016
• Subjects: Biocompatible Materials; Composite materials; Enzymes; Fibrinolysis - drug effects; Fibrinolytic Agents - therapeutic use; Humans; Magnetite Nanoparticles - chemistry; Magnetite Nanoparticles - therapeutic use; Nanocomposites; Nanoparticles; Pore size; Thrombolytic Therapy - methods; Thrombosis - drug therapy
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep28119

Despite the fact that magnetic thrombolytic composites is an emerging area, all known so far systems are based on the similar mechanism of action: thrombolytic enzyme releases from the magnetic carrier leaving non-active matrix, thus making the whole system active only for a limited period of time. Such systems often have very complex structure organization and composition, consisting of materials not approved for parenteral injection, making them poor candidates for real clinical trials and implementation. Here we report, for the first time, the production of thrombolytic magnetic composite material with non-releasing behavior and prolonged action. Obtained composite shows good thrombolytic activity, consists of fully biocompatible materials and could be applied as infinitely active thrombolytic coatings or magnetically-targetable thrombolytic agents.