ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation

• Published in: Brain, behavior, and immunity Vol. 93; pp. 312 - 321
• Main Authors: Cui, Yu, Zhang, Yan, Zhao, Xiaolong, Shao, Liming, Liu, Guoping, Sun, Chengjian, Xu, Rui, Zhang, Zhaolong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.03.2021
• Subjects: ACSL4; Animals; Brain Injuries; Brain Ischemia; Coenzyme A Ligases - genetics; Ferroptosis; Ischemic Stroke; Mice; Neuroinflammation; Ferroptosis; Neuroinflammation; ACSL4; Ischemic stroke

•The expression of ACSL4 was decreased after ischemia which was mediated by HIF-1α.•Overexpression of ACSL4 exacerbated ischemic brain injury.•Knockdown of ACSL4 reduced ischemic brain injury.•ACSL4 promoted neuronal ferroptosis and microglia-mediated neuroinflammation. Acyl-CoA synthetase long-chai...