Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01

• Published in: The Journal of infectious diseases Vol. 213; no. 11; pp. 1743 - 1751
• Main Authors: Payne, Ruth O., Milne, Kathryn H., Elias, Sean C., Edwards, Nick J., Douglas, Alexander D., Brown, Rebecca E., Silk, Sarah E., Biswas, Sumi, Miura, Kazutoyo, Roberts, Rachel, Rampling, Thomas W., Venkatraman, Navin, Hodgson, Susanne H., Labbé, Geneviève M., Halstead, Fenella D., Poulton, Ian D., Nugent, Fay L., de Graaf, Hans, Sukhtankar, Priya, Williams, Nicola C., Ockenhouse, Christian F., Kathcart, April K., Qabar, Aziz N., Waters, Norman C., Soisson, Lorraine A., Birkett, Ashley J., Cooke, Graham S., Faust, Saul N., Woods, Colleen, Ivinson, Karen, McCarthy, James S., Diggs, Carter L., Vekemans, Johan, Long, Carole A., Hill, Adrian V. S., Lawrie, Alison M., Dutta, Sheetij, Draper, Simon J.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.06.2016
• Subjects: Adult; Antigens, Protozoan - immunology; Enzyme-Linked Immunospot Assay; Erythrocytes - parasitology; Female; Humans; Immunogenicity, Vaccine; Life Cycle Stages; Major and Brief Reports; Malaria Vaccines - immunology; Malaria, Falciparum - parasitology; Malaria, Falciparum - prevention & control; Male; Membrane Proteins - immunology; Middle Aged; Models, Biological; PARASITES; Plasmodium falciparum; Plasmodium falciparum - immunology; Plasmodium falciparum - physiology; Protozoan Proteins - immunology; Young Adult; AMA1; vaccine; blood stage; malaria; CHMI

Background. Models of controlled human malaria infection (CHMI) initiated by mosquito bite have been widely used to assess efficacy of preerythrocytic vaccine candidates in small proof-of-concept phase 2a clinical trials. Efficacy testing of blood-stage malaria parasite vaccines, however, has genera...