Utility of exhaled nitric oxide as a noninvasive biomarker of lung inflammation in a disease model

• Published in: The European respiratory journal Vol. 28; no. 6; pp. 1236 - 1244
• Main Authors: Birrell, M. A, McCluskie, K, Hardaker, E, Knowles, R, Belvisi, M. G
• Format: Journal Article
• Language: English
• Published: Leeds Eur Respiratory Soc 01.12.2006; Maney
• Subjects: Amides - pharmacology; Animals; Anti-Inflammatory Agents - pharmacology; Biological and medical sciences; Biomarkers - metabolism; Budesonide - pharmacology; Disease Models, Animal; Exhalation; Lipopolysaccharides - pharmacology; Medical sciences; Nitric Oxide - metabolism; Pneumology; Pneumonia - diagnosis; Pneumonia - metabolism; Rats; Rats, Wistar; Respiratory System - metabolism; Thiophenes - pharmacology; Lung disease; Rat; Respiratory disease; Rodentia; Biological marker; Inflammation; biomarker; Airway; Vertebrata; Mammalia; Animal; Nitric oxide; Non invasive method; Models; rats; exhaled; Pneumology

There is a great deal of interest in developing less invasive markers for monitoring airway inflammation and the effect of possible novel anti-inflammatory therapies that may take time to impact on disease pathology. Exhaled nitric oxide (eNO) has been shown to be a reproducible, noninvasive indicat...