Effects of early life adversity and FKBP5 genotype on hippocampal subfields volume in major depression

• Published in: Journal of affective disorders Vol. 252; pp. 152 - 159
• Main Authors: Mikolas, Pavol, Tozzi, Leonardo, Doolin, Kelly, Farrell, Chloe, O'Keane, Veronica, Frodl, Thomas
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2019
• Subjects: Adult; Amygdala - pathology; Dentate Gyrus - pathology; Depressive Disorder, Major - genetics; Depressive Disorder, Major - pathology; Early life adversity; Female; FKBP5; Genotype; Hippocampal subfields; Hippocampus; Hippocampus - pathology; Humans; Magnetic Resonance Imaging; Major depression; Male; Middle Aged; Neuronal Plasticity - genetics; Organ Size; rs1360780; Stress, Psychological - genetics; Tacrolimus Binding Proteins - genetics; Temporal Lobe - pathology; Early life adversity; Hippocampal subfields; rs1360780; Major depression; Hippocampus; FKBP5

•MDD patients had smaller volumes within the cornu ammonis and dentate gyrus.•MDD exposed to early life adversity had larger hippocampi and their subfields.•There was an interaction of FKBP5 and early life adversity in the HATA subfield. Smaller hippocampus volume represents a consistent finding in...