Fluorine-19 Cellular MRI Detection of In Vivo Dendritic Cell Migration and Subsequent Induction of Tumor Antigen-Specific Immunotherapeutic Response

• Published in: Molecular imaging and biology Vol. 22; no. 3; pp. 549 - 561
• Main Authors: Fink, Corby, Smith, Michael, Gaudet, Jeffrey M., Makela, Ashley, Foster, Paula J., Dekaban, Gregory A.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2020; Springer Nature B.V
• Subjects: Antigens; Bearing (direction); Bone marrow; Cancer; Cancer immunotherapy; Cell adhesion & migration; Cell culture; Cell migration; Dendritic cells; Fluorine; Imaging; Immune response; Immune system; Immunization; Immunotherapy; Magnetic resonance imaging; Medical imaging; Medicine; Medicine & Public Health; Melanoma; Microscopy; NMR; Nuclear magnetic resonance; Optimization; Osteoprogenitor cells; Perfluorocarbons; Phenotypes; Phenotyping; Radiology; Research Article; Tracking; Tumors; Viability; Dendritic cell (DC); Fluorine-19 (F-19); Cancer immunotherapy; Cellular magnetic resonance imaging (MRI)

Purpose A major hurdle in the advancement of cell-based cancer immunotherapies is the inability to track in vivo therapeutic cell migration. With respect to dendritic cell (DC)-based cancer immunotherapies, this lack of knowledge represents an even greater hurdle as the quantity of tumor-antigen spe...