Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions

The therapeutic efficacy of systemic drug-delivery vehicles depends on their ability to evade the immune system, cross the biological barriers of the body and localize at target tissues. White blood cells of the immune system—known as leukocytes—possess all of these properties and exert their target...

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Published in	Nature nanotechnology Vol. 8; no. 1; pp. 61 - 68
Main Authors	Parodi, Alessandro, Quattrocchi, Nicoletta, van de Ven, Anne L., Chiappini, Ciro, Evangelopoulos, Michael, Martinez, Jonathan O., Brown, Brandon S., Khaled, Sm Z., Yazdi, Iman K., Enzo, Maria Vittoria, Isenhart, Lucas, Ferrari, Mauro, Tasciotti, Ennio
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 01.01.2013 Nature Publishing Group
Subjects	639/925/352/152 639/925/352/2733 639/925/357/354 Animals Biodistribution Biological Transport Biomimetics Biomimetics - methods Cell Adhesion Endothelium Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Human Umbilical Vein Endothelial Cells Humans Immune system Leukocytes Leukocytes - chemistry Leukocytes - metabolism Liver - chemistry Liver - metabolism Liver Neoplasms, Experimental - chemistry Liver Neoplasms, Experimental - metabolism Materials Science Membranes Membranes, Artificial Mice Mice, Inbred C57BL Models, Biological Nanoparticles Nanoparticles - chemistry Nanotechnology Nanotechnology and Microengineering Phagocytosis Polyethylene glycol Proteins Silicon Tumors United States > US Italy Texas
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Abstract	The therapeutic efficacy of systemic drug-delivery vehicles depends on their ability to evade the immune system, cross the biological barriers of the body and localize at target tissues. White blood cells of the immune system—known as leukocytes—possess all of these properties and exert their targeting ability through cellular membrane interactions. Here, we show that nanoporous silicon particles can successfully perform all these actions when they are coated with cellular membranes purified from leukocytes. These hybrid particles, called leukolike vectors, can avoid being cleared by the immune system. Furthermore, they can communicate with endothelial cells through receptor–ligand interactions, and transport and release a payload across an inflamed reconstructed endothelium. Moreover, leukolike vectors retained their functions when injected in vivo , showing enhanced circulation time and improved accumulation in a tumour. Camouflaging nanoporous silicon particles by functionalizing them with membranes isolated from white blood cells can delay their removal from the body and improve their accumulation in tumours.
AbstractList	The therapeutic efficacy of systemic drug-delivery vehicles depends on their ability to evade the immune system, cross the biological barriers of the body and localize at target tissues. White blood cells of the immune system--known as leukocytes--possess all of these properties and exert their targeting ability through cellular membrane interactions. Here, we show that nanoporous silicon particles can successfully perform all these actions when they are coated with cellular membranes purified from leukocytes. These hybrid particles, called leukolike vectors, can avoid being cleared by the immune system. Furthermore, they can communicate with endothelial cells through receptor-ligand interactions, and transport and release a payload across an inflamed reconstructed endothelium. Moreover, leukolike vectors retained their functions when injected in vivo, showing enhanced circulation time and improved accumulation in a tumour. The therapeutic efficacy of systemic drug-delivery vehicles depends on their ability to evade the immune system, cross the biological barriers of the body and localize at target tissues. White blood cells of the immune system—known as leukocytes—possess all of these properties and exert their targeting ability through cellular membrane interactions. Here, we show that nanoporous silicon particles can successfully perform all these actions when they are coated with cellular membranes purified from leukocytes. These hybrid particles, called leukolike vectors, can avoid being cleared by the immune system. Furthermore, they can communicate with endothelial cells through receptor–ligand interactions, and transport and release a payload across an inflamed reconstructed endothelium. Moreover, leukolike vectors retained their functions when injected in vivo , showing enhanced circulation time and improved accumulation in a tumour. Camouflaging nanoporous silicon particles by functionalizing them with membranes isolated from white blood cells can delay their removal from the body and improve their accumulation in tumours.
Author	Isenhart, Lucas Chiappini, Ciro Martinez, Jonathan O. Quattrocchi, Nicoletta van de Ven, Anne L. Khaled, Sm Z. Enzo, Maria Vittoria Yazdi, Iman K. Tasciotti, Ennio Evangelopoulos, Michael Parodi, Alessandro Ferrari, Mauro Brown, Brandon S.
Author_xml	– sequence: 1 givenname: Alessandro surname: Parodi fullname: Parodi, Alessandro organization: Department of Nanomedicine, The Methodist Hospital System Research Institute, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori – sequence: 2 givenname: Nicoletta surname: Quattrocchi fullname: Quattrocchi, Nicoletta organization: Department of Nanomedicine, The Methodist Hospital System Research Institute, Department of Experimental Medicine, University of Milano Bicocca – sequence: 3 givenname: Anne L. surname: van de Ven fullname: van de Ven, Anne L. organization: Department of Nanomedicine, The Methodist Hospital System Research Institute – sequence: 4 givenname: Ciro surname: Chiappini fullname: Chiappini, Ciro organization: Department of Nanomedicine, The Methodist Hospital System Research Institute, Present address: Department of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ, UK – sequence: 5 givenname: Michael surname: Evangelopoulos fullname: Evangelopoulos, Michael organization: Department of Nanomedicine, The Methodist Hospital System Research Institute – sequence: 6 givenname: Jonathan O. surname: Martinez fullname: Martinez, Jonathan O. organization: Department of Nanomedicine, The Methodist Hospital System Research Institute, The University of Texas Health Science Center at Houston – sequence: 7 givenname: Brandon S. surname: Brown fullname: Brown, Brandon S. organization: Department of Nanomedicine, The Methodist Hospital System Research Institute, The University of Texas Health Science Center at Houston – sequence: 8 givenname: Sm Z. surname: Khaled fullname: Khaled, Sm Z. organization: Department of Nanomedicine, The Methodist Hospital System Research Institute – sequence: 9 givenname: Iman K. surname: Yazdi fullname: Yazdi, Iman K. organization: Department of Nanomedicine, The Methodist Hospital System Research Institute, Department of Biomedical Engineering, University of Houston – sequence: 10 givenname: Maria Vittoria surname: Enzo fullname: Enzo, Maria Vittoria organization: Department of Nanomedicine, The Methodist Hospital System Research Institute, Department of Oncological and Surgical Sciences, 2nd Surgical Clinic, University of Padua – sequence: 11 givenname: Lucas surname: Isenhart fullname: Isenhart, Lucas organization: Department of Nanomedicine, The Methodist Hospital System Research Institute – sequence: 12 givenname: Mauro surname: Ferrari fullname: Ferrari, Mauro organization: Department of Nanomedicine, The Methodist Hospital System Research Institute – sequence: 13 givenname: Ennio surname: Tasciotti fullname: Tasciotti, Ennio email: etasciotti@tmhs.org organization: Department of Nanomedicine, The Methodist Hospital System Research Institute
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/23241654$$D View this record in MEDLINE/PubMed
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Snippet	The therapeutic efficacy of systemic drug-delivery vehicles depends on their ability to evade the immune system, cross the biological barriers of the body and...
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SubjectTerms	639/925/352/152 639/925/352/2733 639/925/357/354 Animals Biodistribution Biological Transport Biomimetics Biomimetics - methods Cell Adhesion Endothelium Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Human Umbilical Vein Endothelial Cells Humans Immune system Leukocytes Leukocytes - chemistry Leukocytes - metabolism Liver - chemistry Liver - metabolism Liver Neoplasms, Experimental - chemistry Liver Neoplasms, Experimental - metabolism Materials Science Membranes Membranes, Artificial Mice Mice, Inbred C57BL Models, Biological Nanoparticles Nanoparticles - chemistry Nanotechnology Nanotechnology and Microengineering Phagocytosis Polyethylene glycol Proteins Silicon Tumors
Title	Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions
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