N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response

• Published in: Molecular cell Vol. 69; no. 4; pp. 636 - 647.e7
• Main Authors: Zhou, Jun, Wan, Ji, Shu, Xin Erica, Mao, Yuanhui, Liu, Xiao-Min, Yuan, Xin, Zhang, Xingqian, Hess, Martin E., Brüning, Jens C., Qian, Shu-Bing
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 15.02.2018
• Subjects: alternative translation; amino acids; ATF4; epitranscriptome; FTO; integrated stress response; m6A; messenger RNA; methylation; methyltransferases; mice; QTI-seq; reinitiation; ribosome scanning; ribosomes; signal transduction; start codon; start codon selection; stress response; transgenic animals; translation (genetics); FTO; alternative translation; QTI-seq; m6A; epitranscriptome; reinitiation; ribosome scanning; ATF4; integrated stress response; start codon selection

The integrated stress response (ISR) facilitates cellular adaptation to stress conditions via the common target eIF2α. During ISR, the selective translation of stress-related mRNAs often relies on alternative mechanisms, such as leaky scanning or reinitiation, but the underlying mechanism remains in...