N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response

The integrated stress response (ISR) facilitates cellular adaptation to stress conditions via the common target eIF2α. During ISR, the selective translation of stress-related mRNAs often relies on alternative mechanisms, such as leaky scanning or reinitiation, but the underlying mechanism remains in...

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Published in	Molecular cell Vol. 69; no. 4; pp. 636 - 647.e7
Main Authors	Zhou, Jun, Wan, Ji, Shu, Xin Erica, Mao, Yuanhui, Liu, Xiao-Min, Yuan, Xin, Zhang, Xingqian, Hess, Martin E., Brüning, Jens C., Qian, Shu-Bing
Format	Journal Article
Language	English
Published	Elsevier Inc 15.02.2018
Subjects	alternative translation amino acids ATF4 epitranscriptome FTO integrated stress response m6A messenger RNA methylation methyltransferases mice QTI-seq reinitiation ribosome scanning ribosomes signal transduction start codon start codon selection stress response transgenic animals translation (genetics) FTO alternative translation QTI-seq m6A epitranscriptome reinitiation ribosome scanning ATF4 integrated stress response start codon selection
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Abstract	The integrated stress response (ISR) facilitates cellular adaptation to stress conditions via the common target eIF2α. During ISR, the selective translation of stress-related mRNAs often relies on alternative mechanisms, such as leaky scanning or reinitiation, but the underlying mechanism remains incompletely understood. Here we report that, in response to amino acid starvation, the reinitiation of ATF4 is not only governed by the eIF2α signaling pathway, but is also subjected to regulation by mRNA methylation in the form of N6-methyladenosine (m6A). While depleting m6A demethylases represses ATF4 reinitiation, knocking down m6A methyltransferases promotes ATF4 translation. We demonstrate that m6A in the 5′ UTR controls ribosome scanning and subsequent start codon selection. Global profiling of initiating ribosomes reveals widespread alternative translation events influenced by dynamic mRNA methylation. Consistently, Fto transgenic mice manifest enhanced ATF4 expression, highlighting the critical role of m6A in translational regulation of ISR at cellular and organismal levels. [Display omitted] •ATF4 reinitiation involves the m6A demethylase ALKBH5•ATF4 reinitiation is sensitive to mRNA m6A levels•Global alternative translation is modulated by 5′ UTR m6A levels•Liver-specific FTO transgenic mice show altered translation initiation Zhou et al. show that amino acid starvation-induced ATF4 translation is subject to regulation by mRNA methylation in the form of m6A. Global analysis of translation initiation reveals that m6A in the 5′ UTR modulates start codon selection, thereby controlling alternative translation.
AbstractList	The integrated stress response (ISR) facilitates cellular adaptation to stress conditions via the common target eIF2α. During ISR, the selective translation of stress-related mRNAs often relies on alternative mechanisms, such as leaky scanning or reinitiation, but the underlying mechanism remains incompletely understood. Here we report that, in response to amino acid starvation, the reinitiation of ATF4 is not only governed by the eIF2α signaling pathway, but is also subjected to regulation by mRNA methylation in the form of N6-methyladenosine (m6A). While depleting m6A demethylases represses ATF4 reinitiation, knocking down m6A methyltransferases promotes ATF4 translation. We demonstrate that m6A in the 5′ UTR controls ribosome scanning and subsequent start codon selection. Global profiling of initiating ribosomes reveals widespread alternative translation events influenced by dynamic mRNA methylation. Consistently, Fto transgenic mice manifest enhanced ATF4 expression, highlighting the critical role of m6A in translational regulation of ISR at cellular and organismal levels. [Display omitted] •ATF4 reinitiation involves the m6A demethylase ALKBH5•ATF4 reinitiation is sensitive to mRNA m6A levels•Global alternative translation is modulated by 5′ UTR m6A levels•Liver-specific FTO transgenic mice show altered translation initiation Zhou et al. show that amino acid starvation-induced ATF4 translation is subject to regulation by mRNA methylation in the form of m6A. Global analysis of translation initiation reveals that m6A in the 5′ UTR modulates start codon selection, thereby controlling alternative translation. The integrated stress response (ISR) facilitates cellular adaptation to stress conditions via the common target eIF2α. During ISR, the selective translation of stress-related mRNAs often relies on alternative mechanisms, such as leaky scanning or reinitiation, but the underlying mechanism remains incompletely understood. Here we report that, in response to amino acid starvation, the reinitiation of ATF4 is not only governed by the eIF2α signaling pathway, but is also subjected to regulation by mRNA methylation in the form of N6-methyladenosine (m6A). While depleting m6A demethylases represses ATF4 reinitiation, knocking down m6A methyltransferases promotes ATF4 translation. We demonstrate that m6A in the 5′ UTR controls ribosome scanning and subsequent start codon selection. Global profiling of initiating ribosomes reveals widespread alternative translation events influenced by dynamic mRNA methylation. Consistently, Fto transgenic mice manifest enhanced ATF4 expression, highlighting the critical role of m6A in translational regulation of ISR at cellular and organismal levels. The integrated stress response (ISR) facilitates cellular adaptation to stress conditions via the common target eIF2α. During ISR, the selective translation of stress-related mRNAs often relies on alternative mechanisms, such as leaky scanning or reinitiation, but the underlying mechanism remains incompletely understood. Here we report that, in response to amino acid starvation, the reinitiation of ATF4 is not only governed by the eIF2α signaling pathway, but is also subjected to regulation by mRNA methylation in the form of N 6 -methyladenosine (m 6 A). While depleting m 6 A demethylases represses ATF4 reinitiation, knocking down m 6 A methyltransferases promotes ATF4 translation. We demonstrate that m 6 A in the 5′ untranslated region (5′UTR) controls ribosome scanning and subsequent start codon selection. Global profiling of initiating ribosomes reveals widespread alternative translation events influenced by dynamic mRNA methylation. Consistently, Fto -transgenic mice manifest enhanced ATF4 expression, highlighting the critical role of m 6 A in translational regulation of ISR at cellular and organismal levels. Zhou et al. show that amino acid starvation-induced ATF4 translation is subject to regulation by mRNA methylation in the form of m 6 A. Global analysis of translation initiation reveals that m 6 A in the 5′UTR modulates start codon selection, thereby controlling alternative translation. The integrated stress response (ISR) facilitates cellular adaptation to stress conditions via the common target eIF2α. During ISR, the selective translation of stress-related mRNAs often relies on alternative mechanisms, such as leaky scanning or reinitiation, but the underlying mechanism remains incompletely understood. Here we report that, in response to amino acid starvation, the reinitiation of ATF4 is not only governed by the eIF2α signaling pathway, but is also subjected to regulation by mRNA methylation in the form of N6-methyladenosine (m6A). While depleting m6A demethylases represses ATF4 reinitiation, knocking down m6A methyltransferases promotes ATF4 translation. We demonstrate that m6A in the 5' UTR controls ribosome scanning and subsequent start codon selection. Global profiling of initiating ribosomes reveals widespread alternative translation events influenced by dynamic mRNA methylation. Consistently, Fto transgenic mice manifest enhanced ATF4 expression, highlighting the critical role of m6A in translational regulation of ISR at cellular and organismal levels.The integrated stress response (ISR) facilitates cellular adaptation to stress conditions via the common target eIF2α. During ISR, the selective translation of stress-related mRNAs often relies on alternative mechanisms, such as leaky scanning or reinitiation, but the underlying mechanism remains incompletely understood. Here we report that, in response to amino acid starvation, the reinitiation of ATF4 is not only governed by the eIF2α signaling pathway, but is also subjected to regulation by mRNA methylation in the form of N6-methyladenosine (m6A). While depleting m6A demethylases represses ATF4 reinitiation, knocking down m6A methyltransferases promotes ATF4 translation. We demonstrate that m6A in the 5' UTR controls ribosome scanning and subsequent start codon selection. Global profiling of initiating ribosomes reveals widespread alternative translation events influenced by dynamic mRNA methylation. Consistently, Fto transgenic mice manifest enhanced ATF4 expression, highlighting the critical role of m6A in translational regulation of ISR at cellular and organismal levels.
Author	Qian, Shu-Bing Wan, Ji Yuan, Xin Liu, Xiao-Min Zhou, Jun Mao, Yuanhui Brüning, Jens C. Zhang, Xingqian Hess, Martin E. Shu, Xin Erica
AuthorAffiliation	2 Max Planck Institute for Metabolism Research, Cologne 50931, Germany 1 Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
AuthorAffiliation_xml	– name: 2 Max Planck Institute for Metabolism Research, Cologne 50931, Germany – name: 1 Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
Author_xml	– sequence: 1 givenname: Jun surname: Zhou fullname: Zhou, Jun organization: Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA – sequence: 2 givenname: Ji surname: Wan fullname: Wan, Ji organization: Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA – sequence: 3 givenname: Xin Erica surname: Shu fullname: Shu, Xin Erica organization: Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA – sequence: 4 givenname: Yuanhui surname: Mao fullname: Mao, Yuanhui organization: Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA – sequence: 5 givenname: Xiao-Min surname: Liu fullname: Liu, Xiao-Min organization: Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA – sequence: 6 givenname: Xin surname: Yuan fullname: Yuan, Xin organization: Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA – sequence: 7 givenname: Xingqian surname: Zhang fullname: Zhang, Xingqian organization: Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA – sequence: 8 givenname: Martin E. surname: Hess fullname: Hess, Martin E. organization: Max Planck Institute for Metabolism Research, Cologne 50931, Germany – sequence: 9 givenname: Jens C. surname: Brüning fullname: Brüning, Jens C. organization: Max Planck Institute for Metabolism Research, Cologne 50931, Germany – sequence: 10 givenname: Shu-Bing surname: Qian fullname: Qian, Shu-Bing email: sq38@cornell.edu organization: Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
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Snippet	The integrated stress response (ISR) facilitates cellular adaptation to stress conditions via the common target eIF2α. During ISR, the selective translation of...
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SubjectTerms	alternative translation amino acids ATF4 epitranscriptome FTO integrated stress response m6A messenger RNA methylation methyltransferases mice QTI-seq reinitiation ribosome scanning ribosomes signal transduction start codon start codon selection stress response transgenic animals translation (genetics)
Title	N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response
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