Extramedullary Hematopoiesis: A New Look at the Underlying Stem Cell Niche, Theories of Development, and Occurrence in Animals

• Published in: Veterinary pathology Vol. 49; no. 3; pp. 508 - 523
• Main Authors: Johns, J. L., Christopher, M. M.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.05.2012
• Subjects: Animals; Cellular Microenvironment - physiology; Chemokines - metabolism; Extracellular Matrix - metabolism; Hematopoiesis, Extramedullary - physiology; Hematopoietic Stem Cells - metabolism; Hematopoietic Stem Cells - physiology; Models, Biological; Signal Transduction - physiology; Species Specificity; Stem Cell Niche - physiology; Stromal Cells - physiology; microenvironment; hematopoietic stem cell; vascular niche; chemokine; CXCL12; spleen

Extramedullary hematopoiesis (EMH) is the formation and development of blood cells outside the medullary spaces of the bone marrow. Although widely considered an epiphenomenon, secondary to underlying primary disease and lacking serious clinical or diagnostic implications, the presence of EMH is far...