microRNA-145 Mediates the Inhibitory Effect of Adipose Tissue-Derived Stromal Cells on Prostate Cancer

• Published in: Stem cells and development Vol. 25; no. 17; p. 1290
• Main Authors: Takahara, Kiyoshi, Ii, Masaaki, Inamoto, Teruo, Nakagawa, Takatoshi, Ibuki, Naokazu, Yoshikawa, Yuki, Tsujino, Takuya, Uchimoto, Taizo, Saito, Kenkichi, Takai, Tomoaki, Tanda, Naoki, Minami, Koichiro, Uehara, Hirofumi, Komura, Kazumasa, Hirano, Hajime, Nomi, Hayahito, Kiyama, Satoshi, Asahi, Michio, Azuma, Haruhito
• Format: Journal Article
• Language: English
• Published: United States 01.09.2016
• Subjects: Adipose Tissue - cytology; Apoptosis - genetics; bcl-X Protein - metabolism; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Disease Progression; Exosomes - metabolism; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; In Situ Nick-End Labeling; Ki-67 Antigen - metabolism; Male; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Stromal Cells - cytology

Adipose-derived stromal cell (ASC), known as one of the mesenchymal stem cells (MSCs), is a promising tool for regenerative medicine; however, the effect of ASCs on tumor growth has not been studied sufficiently. We investigated the hypothesis that ASCs have an inhibitory effect on metastatic tumor...