Neural network disturbance in the medial prefrontal cortex might contribute to cognitive impairments induced by neuroinflammation

• Published in: Brain, behavior, and immunity Vol. 89; pp. 133 - 144
• Main Authors: Ji, Mu-huo, Lei, Lei, Gao, Da-peng, Tong, Jian-hua, Wang, Yong, Yang, Jian-jun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.10.2020
• Subjects: Animals; Cognitive Dysfunction - chemically induced; Cognitive impairment; Interneurons - metabolism; Neural network; Neural Networks, Computer; Neuroinflammation; Parvalbumin; Parvalbumins - metabolism; Prefrontal Cortex - metabolism; Neuroinflammation; Neural network; Parvalbumin; Cognitive impairment

•Neuroinflammation plays a key role in many neurodegenerative diseases.•LPS decreased intensities of vesicular GABA transporter and PV buttons.•LPS induced abnormal mPFC neural activities and cognitive impairments.•Down-regulation of neuroinflammation improved cognitive performance.•Boosting gamma o...