Which Patients with Prostate Cancer and Lymph Node Uptake at Preoperative Prostate-specific Membrane Antigen Positron Emission Tomography/Computerized Tomography Scan Are at a Higher Risk of Prostate-specific Antigen Persistence After Radical Prostatectomy? Identifying Indicators of Systemic Disease by Integrating Clinical, Magnetic Resonance Imaging, and Functional Imaging Parameters

• Published in: European urology oncology Vol. 7; no. 2; pp. 231 - 240
• Main Authors: Mazzone, Elio, Gandaglia, Giorgio, Robesti, Daniele, Rajwa, Pawel, Gomez Rivas, Juan, Ibáñez, Laura, Soeterik, Timo F.W., Bianchi, Lorenzo, Afferi, Luca, Kesch, Claudia, Darr, Christopher, Guo, Hongqian, Zhuang, Junlong, Zattoni, Fabio, Fendler, Wolfgang P., Amparore, Daniele, Huebner, Nicolai A., Giesen, Alexander, Joniau, Steven, Schiavina, Riccardo, Brunocilla, Eugenio, Mattei, Agostino, Dal Moro, Fabrizio, Moreno Sierra, Jesus, Porpiglia, Francesco, Picchio, Maria, Chiti, Arturo, van den Bergh, Roderick, Shariat, Shahrokh F., Montorsi, Francesco, Briganti, Alberto
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2024
• Subjects: Humans; Lymph Nodes - diagnostic imaging; Lymph Nodes - pathology; Lymph Nodes - surgery; Lymphadenopathy - pathology; Lymphadenopathy - surgery; Lymphatic Metastasis - pathology; Magnetic Resonance Imaging; Male; Multiparametric magnetic resonance imaging; Nomogram; Positron Emission Tomography Computed Tomography - methods; Positron-Emission Tomography; Prostate - diagnostic imaging; Prostate - pathology; Prostate - surgery; Prostate cancer; Prostate-Specific Antigen; Prostate-specific antigen persistence; Prostate-specific membrane antigen positron emission tomography; Prostatectomy; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - pathology; Prostatic Neoplasms - surgery; Risk category; Seminal Vesicles - pathology; Prostate-specific membrane antigen positron emission tomography; Multiparametric magnetic resonance imaging; Risk category; Prostate cancer; Nomogram; Prostate-specific antigen persistence

Our novel and straightforward risk classification integrates currently available preoperative risk tools and can help in identifying patients with miN1 disease in whom radical prostatectomy may achieve the best oncological outcomes in the context of a multimodal approach. Therefore, it can assist ph...