Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1

• Published in: Cancer research (Chicago, Ill.) Vol. 77; no. 18; pp. 4868 - 4880
• Main Authors: Si, Yuan, Ji, Xinyan, Cao, Xiaolei, Dai, Xiaoming, Xu, Lingyi, Zhao, Hongxia, Guo, Xiaocan, Yan, Huan, Zhang, Haitao, Zhu, Chu, Zhou, Qi, Tang, Mei, Xia, Zongping, Li, Li, Cong, Yu-Sheng, Ye, Sheng, Liang, Tingbo, Feng, Xin-Hua, Zhao, Bin
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research, Inc 15.09.2017
• Subjects: AACR; Adaptor Proteins, Signal Transducing - metabolism; Animal models; Animals; Apoptosis; Biomarkers, Tumor - metabolism; Breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Adhesion; Cell adhesion & migration; Cell Proliferation; Cell Self Renewal; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Cells, Cultured; Female; HEK293 Cells; Humans; Kinases; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Staging; Phosphoproteins - metabolism; Phosphorylation; Prognosis; Protein-Serine-Threonine Kinases - metabolism; Protein-tyrosine kinase; Signal Transduction; Src protein; src-Family Kinases - metabolism; Stem cells; Transcription; Transcription Factors; Tumor suppressor genes; Tumorigenesis; Tyrosine - metabolism; Xenograft Model Antitumor Assays; Yes-associated protein

The Hippo pathway regulates cell proliferation, apoptosis, and stem cell self-renewal, and its inactivation in animal models causes organ enlargement followed by tumorigenesis. Hippo pathway deregulation occurs in many human cancers, but the underlying mechanisms are not fully understood. Here, we r...