Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of aging

• Published in: Experimental biology and medicine (Maywood, N.J.) Vol. 238; no. 5; p. 450
• Main Authors: Wang, Chih-Hao, Wu, Shi-Bei, Wu, Yu-Ting, Wei, Yau-Huei
• Format: Journal Article
• Language: English
• Published: England 01.05.2013
• Subjects: Animals; Apoptosis - genetics; Autophagy - genetics; DNA, Mitochondrial - genetics; DNA, Mitochondrial - metabolism; Humans; Longevity; Mitochondria - genetics; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial Degradation - genetics; Mutation; Oxidative Stress; Protein Processing, Post-Translational; Reactive Oxygen Species - metabolism; mtDNA mutation; vicious cycle; autophagy; caloric restriction; Aging; mitochondrial dysfunction; oxidative stress

Under normal physiological conditions, reactive oxygen species (ROS) serve as 'redox messengers' in the regulation of intracellular signalling, whereas excess ROS may induce irreversible damage to cellular components and lead to cell death by promoting the intrinsic apoptotic pathway throu...