Protein kinase C is not involved in secretion by permeabilized human neutrophils

• Published in: Cellular signalling Vol. 1; no. 5; pp. 471 - 481
• Main Authors: Smolen, James E., Stoehr, Sally Jo, Bartone, Dana
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 1989
• Subjects: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate - physiology; Cell Membrane Permeability - physiology; degranulation; Diglycerides - pharmacology; Glucuronidase - secretion; guanine nucleotides; Humans; intracellular Ca 2; Isoquinolines - pharmacology; Lysosomes - drug effects; Lysosomes - enzymology; Lysosomes - metabolism; Magnesium - physiology; Muramidase - secretion; Neutrophil; Neutrophils - metabolism; permeabilization; phospholipase C; Piperazines - pharmacology; protein kinase C; Protein Kinase C - antagonists & inhibitors; Protein Kinase C - physiology; Tetradecanoylphorbol Acetate - pharmacology; Transcobalamins - secretion; Type C Phospholipases - physiology; phospholipase C; intracellular Ca 2; Neutrophil; degranulation; guanine nucleotides; permeabilization; protein kinase C

The generally accepted sequence of intracellular signal transduction involves: (1) cell surface receptor-ligand interaction; (2) activation of G-proteins; (3) activation of phospholipase C, leading to inositol phosphate (IP 3) and diacylglycerol production; (4) parallel mobilization of intracellular...