High mutation prevalence of precore and basal core promoter in pregnant women who underwent spontaneous HBeAg seroconversion within one year postpartum

• Published in: Digestive and liver disease Vol. 52; no. 2; pp. 199 - 204
• Main Authors: Luo, Yuqian, Pan, Mingjie, Ning, Mingzhe, Chenyu, Xu, Liu, Lanhua, Chen, Liping, Chen, Tingmei, Biyun, Xu, Yali, Hu, Zhou, Yi-Hua
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.02.2020
• Subjects: Adult; Female; Hepatitis B e Antigens - blood; Hepatitis B infection; Hepatitis B Surface Antigens - blood; Hepatitis B virus - genetics; Hepatitis B, Chronic - blood; Hepatitis B, Chronic - virology; Humans; Logistic Models; Mutation; PC/BCP mutation; Postpartum Period; Postpartum spontaneous HBeAg seroconversion; Pregnancy; Pregnancy Complications, Infectious - blood; Pregnancy Complications, Infectious - virology; Prevalence; Promoter Regions, Genetic; ROC Curve; Seroconversion; Young Adult; Postpartum spontaneous HBeAg seroconversion; Hepatitis B infection; PC/BCP mutation

Seroconversion of hepatitis B e antigen (HBeAg) is a critical event in the natural course of hepatitis B virus (HBV) infection. We herein characterize the virological factors associated with postpartum spontaneous HBeAg seroconversion. A total of 214 pregnant women positive for both hepatitis B surf...