Seed Dormancy in Arabidopsis Is Controlled by Alternative Polyadenylation of DOG1
DOG1 (Delay of Germination 1) is a key regulator of seed dormancy in Arabidopsis (Arabidopsis thaliana) and other plants. Interestingly, the C terminus of DOG1 is either absent or not conserved in many plant species. Here, we show that in Arabidopsis, DOG1 transcript is subject to alternative polyad...
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| Published in | Plant physiology (Bethesda) Vol. 170; no. 2; pp. 947 - 955 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Society of Plant Biologists
01.02.2016
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| Abstract | DOG1 (Delay of Germination 1) is a key regulator of seed dormancy in Arabidopsis (Arabidopsis thaliana) and other plants. Interestingly, the C terminus of DOG1 is either absent or not conserved in many plant species. Here, we show that in Arabidopsis, DOG1 transcript is subject to alternative polyadenylation. In line with this, mutants in RNA 3ʹ processing complex display weakened seed dormancy in parallel with defects in DOG1 proximal polyadenylation site selection, suggesting that the short DOG1 transcript is functional. This is corroborated by the finding that the proximally polyadenylated short DOG1 mRNA is translated in vivo and complements the dog1 mutant. In summary, our findings indicate that the short DOG1 protein isoform produced from the proximally polyadenylated DOG1 mRNA is a key player in the establishment of seed dormancy in Arabidopsis and characterizes a set of mutants in RNA 3ʹ processing complex required for production of proximally polyadenylated functional DOG1 transcript. |
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| AbstractList | A major quantitative trait locus is alternatively polyadenylated and its proximally polyadenylated form is required for seed dormancy.
DOG1 (Delay of Germination 1) is a key regulator of seed dormancy in Arabidopsis (
Arabidopsis thaliana
) and other plants. Interestingly, the C terminus of DOG1 is either absent or not conserved in many plant species. Here, we show that in Arabidopsis,
DOG1
transcript is subject to alternative polyadenylation. In line with this, mutants in RNA 3′ processing complex display weakened seed dormancy in parallel with defects in
DOG1
proximal polyadenylation site selection, suggesting that the short
DOG1
transcript is functional. This is corroborated by the finding that the proximally polyadenylated short
DOG1
mRNA is translated in vivo and complements the
dog1
mutant. In summary, our findings indicate that the short DOG1 protein isoform produced from the proximally polyadenylated
DOG1
mRNA is a key player in the establishment of seed dormancy in Arabidopsis and characterizes a set of mutants in RNA 3′ processing complex required for production of proximally polyadenylated functional
DOG1
transcript. DOG1 (Delay of Germination 1) is a key regulator of seed dormancy in Arabidopsis (Arabidopsis thaliana) and other plants. Interestingly, the C terminus of DOG1 is either absent or not conserved in many plant species. Here, we show that in Arabidopsis, DOG1 transcript is subject to alternative polyadenylation. In line with this, mutants in RNA 3ʹ processing complex display weakened seed dormancy in parallel with defects in DOG1 proximal polyadenylation site selection, suggesting that the short DOG1 transcript is functional. This is corroborated by the finding that the proximally polyadenylated short DOG1 mRNA is translated in vivo and complements the dog1 mutant. In summary, our findings indicate that the short DOG1 protein isoform produced from the proximally polyadenylated DOG1 mRNA is a key player in the establishment of seed dormancy in Arabidopsis and characterizes a set of mutants in RNA 3ʹ processing complex required for production of proximally polyadenylated functional DOG1 transcript. DOG1 (Delay of Germination 1) is a key regulator of seed dormancy in Arabidopsis (Arabidopsis thaliana) and other plants. Interestingly, the C terminus of DOG1 is either absent or not conserved in many plant species. Here, we show that in Arabidopsis, DOG1 transcript is subject to alternative polyadenylation. In line with this, mutants in RNA 3' processing complex display weakened seed dormancy in parallel with defects in DOG1 proximal polyadenylation site selection, suggesting that the short DOG1 transcript is functional. This is corroborated by the finding that the proximally polyadenylated short DOG1 mRNA is translated in vivo and complements the dog1 mutant. In summary, our findings indicate that the short DOG1 protein isoform produced from the proximally polyadenylated DOG1 mRNA is a key player in the establishment of seed dormancy in Arabidopsis and characterizes a set of mutants in RNA 3' processing complex required for production of proximally polyadenylated functional DOG1 transcript.DOG1 (Delay of Germination 1) is a key regulator of seed dormancy in Arabidopsis (Arabidopsis thaliana) and other plants. Interestingly, the C terminus of DOG1 is either absent or not conserved in many plant species. Here, we show that in Arabidopsis, DOG1 transcript is subject to alternative polyadenylation. In line with this, mutants in RNA 3' processing complex display weakened seed dormancy in parallel with defects in DOG1 proximal polyadenylation site selection, suggesting that the short DOG1 transcript is functional. This is corroborated by the finding that the proximally polyadenylated short DOG1 mRNA is translated in vivo and complements the dog1 mutant. In summary, our findings indicate that the short DOG1 protein isoform produced from the proximally polyadenylated DOG1 mRNA is a key player in the establishment of seed dormancy in Arabidopsis and characterizes a set of mutants in RNA 3' processing complex required for production of proximally polyadenylated functional DOG1 transcript. DOG1 (Delay of Germination 1) is a key regulator of seed dormancy in Arabidopsis (Arabidopsis thaliana) and other plants. Interestingly, the C terminus of DOG1 is either absent or not conserved in many plant species. Here, we show that in Arabidopsis, DOG1 transcript is subject to alternative polyadenylation. In line with this, mutants in RNA 3' processing complex display weakened seed dormancy in parallel with defects in DOG1 proximal polyadenylation site selection, suggesting that the short DOG1 transcript is functional. This is corroborated by the finding that the proximally polyadenylated short DOG1 mRNA is translated in vivo and complements the dog1 mutant. In summary, our findings indicate that the short DOG1 protein isoform produced from the proximally polyadenylated DOG1 mRNA is a key player in the establishment of seed dormancy in Arabidopsis and characterizes a set of mutants in RNA 3' processing complex required for production of proximally polyadenylated functional DOG1 transcript. |
| Author | Cyrek, Malgorzata Krzyczmonik, Katarzyna Fedak, Halina Liu, Fuquan Guo, Yanwu Sliwa, Aleksandra Pietras, Zbigniew Ciesielski, Arkadiusz Kaczanowski, Szymon Brzezniak, Lien Swiezewski, Szymon |
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| Copyright | Copyright © 2016 American Society of Plant Biologists 2016 American Society of Plant Biologists. All Rights Reserved. 2016 American Society of Plant Biologists. All Rights Reserved. 2016 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 The author responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (www.plantphysiol.org) is: Szymon Swiezewski (sswiez@ibb.waw.pl). Present address: Friedrich Miescher Institute, 4002 Basel, Switzerland. www.plantphysiol.org/cgi/doi/10.1104/pp.15.01483 S.S. and F.L. designed the project and planned the program of research; H.F., M.C., and A.S. performed the germination tests and expression level measurements; H.F. and M.C. performed the western blots; L.B. did the RACE experiment; S.S. and S.K. performed the bioinformatics analysis; A.C. and H.F. examined localization; G.Y. performed the DOG1-GFP IP; L.B. and A.S. performed the RNA stability assay; K.K and Z.P. prepared the short and long DOG1 lines for complementation; S.S. and M.C. wrote the article. This work was supported by MSHE (grant nos. IdP2011–000461 and 2011/01/D/NZ8/03690 to S.S.). H.F., M.C., A.S., and Z.P. were supported by Foundation for Polish Science Grant Number TEAM2010–5/9. L.B. was supported by IP2011 004671. S.S. was supported by EMBO Installation Grant CEBM/05/17. These authors contributed equally to the article. |
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| Snippet | DOG1 (Delay of Germination 1) is a key regulator of seed dormancy in Arabidopsis (Arabidopsis thaliana) and other plants. Interestingly, the C terminus of DOG1... A major quantitative trait locus is alternatively polyadenylated and its proximally polyadenylated form is required for seed dormancy. DOG1 (Delay of... |
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| SubjectTerms | Amino Acid Sequence Arabidopsis - genetics Arabidopsis - physiology Arabidopsis Proteins - chemistry Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Base Sequence Conserved Sequence Gene Expression Regulation, Plant GENES, DEVELOPMENT AND EVOLUTION Germination Molecular Sequence Data Mutation - genetics Phenotype Plant Dormancy - genetics Polyadenylation - genetics Protein Biosynthesis Protein Isoforms - genetics Protein Isoforms - metabolism RNA Processing, Post-Transcriptional RNA, Messenger - genetics RNA, Messenger - metabolism Seeds - genetics Seeds - physiology |
| Title | Seed Dormancy in Arabidopsis Is Controlled by Alternative Polyadenylation of DOG1 |
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