Cytoplasmic mtDNA clearance suppresses inflammatory immune responses

• Published in: Trends in cell biology Vol. 34; no. 11; pp. 897 - 900
• Main Authors: Yan, Chenghao, Liu, Xu, Xu, Haodong, Wang, Liming
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2024
• Subjects: Animals; Autophagy; autophagy–lysosome pathway; cGAS–STING pathway; Cytoplasm - metabolism; DNA, Mitochondrial - genetics; DNA, Mitochondrial - metabolism; Humans; Inflammation - metabolism; Inflammation - pathology; Lysosomes - metabolism; Mitochondria - metabolism; mtDNA; cGAS–STING pathway; mtDNA; autophagy–lysosome pathway

Upon various stresses, mtDNA leaks from mitochondria into the cytoplasm, leading to cellular dysfunction and inflammation, thereby exacerbating disease progression. The autophagy–lysosome pathway has emerged as a pivotal quality control mechanism for eliminating abnormal cytoplasmic mtDNA. This arti...