Evaluation of 4-methylcyclohexanemethanol (MCHM) in a combined irritancy and Local Lymph Node Assay (LLNA) in mice

• Published in: Food and chemical toxicology Vol. 105; pp. 99 - 105
• Main Authors: Johnson, Victor J., Auerbach, Scott S., Luster, Michael I., Waidyanatha, Suramya, Masten, Scott A., Wolfe, Mary S., Burleson, Florence G., Burleson, Gary R., Germolec, Dori R.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2017
• Subjects: 4-Methylcyclohexanemethanol; Allergic contact; Animals; Cyclohexanes - analysis; Cyclohexanes - toxicity; Dermal hypersensitivity; Dermal irritancy; Dermatitis (ACD); Dermatitis, Allergic Contact - etiology; Elk River spill; Female; Humans; Irritants - analysis; Irritants - toxicity; Local Lymph Node Assay; Local Lymph Node Assay (LLNA); Mice; Mice, Inbred BALB C; Skin Irritancy Tests; Water Pollutants, Chemical - analysis; Water Pollutants, Chemical - toxicity; DPM; AOO; Local Lymph Node Assay (LLNA); ACD; CDC; Elk River spill; DNFB; NTP; Dermal irritancy; Dermal hypersensitivity; LLNA; 4-Methylcyclohexanemethanol; Dermatitis (ACD); SI; ICCVAM; Allergic contact; 125IUdR; MCHM

4-Methylcyclohexanemethanol (MCHM) is a flotation reagent used in fine coal beneficiation. On January 9, 2014, crude MCHM, a mixture containing predominantly MCHM, was inadvertently released into the Elk River, a municipal water source that serves about 300,000 people in the Charleston, WV area, res...