Overexpression of miR-4433 by suberoylanilide hydroxamic acid suppresses growth of CML cells and induces apoptosis through targeting Bcr-Abl

• Published in: Journal of Cancer Vol. 10; no. 23; pp. 5671 - 5680
• Main Authors: Wu, Haiyan, Yin, Jingyi, Ai, Zhengdong, Li, Guiming, Li, Yan, Chen, Li
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2019; Ivyspring International Publisher
• Subjects: Apoptosis; Cell growth; DNA methylation; Kinases; MicroRNAs; Research Paper; Beijing China; United States > US; China; SAHA; Bcr-Abl; apoptosis; chronic myelogenous leukemia; miR-4433; growth

: Targeting Bcr-Abl is the key for the treatment of CML. Although great progress has been achieved for the treatment of CML patients in chronic stage, effective drugs with good safety are not available for those in advanced stages of CML patients. In present study, a histone deacetylase inhibitor, s...