Baseline Predictors of Glycemic Worsening in Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study

• Published in: Diabetes care Vol. 44; no. 9; pp. 1938 - 1947
• Main Authors: Sam, Susan, Edelstein, Sharon L, Arslanian, Silva A, Barengolts, Elena, Buchanan, Thomas A, Caprio, Sonia, Ehrmann, David A, Hannon, Tamara S, Tjaden, Ashley Hogan, Kahn, Steven E, Mather, Kieren J, Tripputi, Mark, Utzschneider, Kristina M, Xiang, Anny H, Nadeau, Kristen J
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.09.2021
• Subjects: Adolescent; Adults; Age; Antidiabetics; Beta cells; Blood Glucose; Child; Chromium; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - drug therapy; Glucose; Glucose Intolerance - diagnosis; Glucose tolerance; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin; Insulin Resistance; Insulin Secretion; Medical diagnosis; Metformin; Research design; Secretion; Young Adult

To identify predictors of glycemic worsening among youth and adults with impaired glucose tolerance (IGT) or recently diagnosed type 2 diabetes in the Restoring Insulin Secretion (RISE) Study. A total of 91 youth (10-19 years) were randomized 1:1 to 12 months of metformin (MET) or 3 months of glargi...