Optimized Dosing Schedule Based on Circadian Dynamics of Mouse Breast Cancer Stem Cells Improves the Antitumor Effects of Aldehyde Dehydrogenase Inhibitor

• Published in: Cancer research (Chicago, Ill.) Vol. 78; no. 13; pp. 3698 - 3708
• Main Authors: Matsunaga, Naoya, Ogino, Takashi, Hara, Yukinori, Tanaka, Takahiro, Koyanagi, Satoru, Ohdo, Shigehiro
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research, Inc 01.07.2018
• Subjects: Aldehyde dehydrogenase; Antitumor activity; Breast cancer; Circadian rhythm; Circadian rhythms; Dehydrogenases; Malignancy; Phenotypes; Stem cell transplantation; Stem cells; Tumor cells

Although malignant phenotypes of triple-negative breast cancer (TNBC) are subject to circadian alterations, the role of cancer stem cells (CSC) in defining this circadian change remains unclear. CSC are often characterized by high aldehyde dehydrogenase (ALDH) activity, which is associated with the...