Soluble Fibre Meal Challenge Reduces Airway Inflammation and Expression of GPR43 and GPR41 in Asthma

• Published in: Nutrients Vol. 9; no. 1; p. 57
• Main Authors: Halnes, Isabel, Baines, Katherine, Berthon, Bronwyn, MacDonald-Wicks, Lesley, Gibson, Peter, Wood, Lisa
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.01.2017; MDPI
• Subjects: Adult; Asthma; Asthma - diet therapy; Asthma - genetics; Body Mass Index; Body Weight; Dietary Fiber - administration & dosage; Fatty acids; Female; Gene expression; Humans; Inflammation; Inflammation - prevention & control; Interleukin-8 - metabolism; Inulin - administration & dosage; Macrophages - metabolism; Male; Meals; Middle Aged; Neutrophils - metabolism; Nitric Oxide - metabolism; Pilot Projects; Probiotics - administration & dosage; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Sputum - metabolism; Up-Regulation; prebiotics; asthma; G-protein coupled receptor; inflammation; short chain fatty acids

Short chain fatty acids (SCFAs) are produced following the fermentation of soluble fibre by gut bacteria. In animal models, both dietary fibre and SCFAs have demonstrated anti-inflammatory effects via the activation of free fatty acid receptors, such as G protein-coupled receptor 41 and 43 (GPR41 an...