Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy

• Published in: Molecular cell Vol. 81; no. 20; pp. 4209 - 4227.e12
• Main Authors: Jiang, Lulu, Lin, Weiwei, Zhang, Cheng, Ash, Peter E.A., Verma, Mamta, Kwan, Julian, van Vliet, Emily, Yang, Zhuo, Cruz, Anna Lourdes, Boudeau, Samantha, Maziuk, Brandon F., Lei, Shuwen, Song, Jaehyup, Alvarez, Victor E., Hovde, Stacy, Abisambra, Jose F., Kuo, Min-Hao, Kanaan, Nicholas, Murray, Melissa E., Crary, John F., Zhao, Jian, Cheng, Ji-Xin, Petrucelli, Leonard, Li, Hu, Emili, Andrew, Wolozin, Benjamin
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 21.10.2021
• Subjects: Alzheimer's disease; brain; fibrils; humans; lamin; METTL3; neurodegeneration; neurodegenerative diseases; nuclear envelope; optogenetics; phosphorylation; protein synthesis; proteomics; RNA methylation; RNA translation; stress granules; stress response; tau oligomerization; lamin; tau oligomerization; METTL3; stress granules; nuclear envelope; RNA translation; neurodegeneration; Alzheimer's disease; RNA methylation; fibrils

The microtubule-associated protein tau oligomerizes, but the actions of oligomeric tau (oTau) are unknown. We have used Cry2-based optogenetics to induce tau oligomers (oTau-c). Optical induction of oTau-c elicits tau phosphorylation, aggregation, and a translational stress response that includes st...