ALDH3A1 acts as a prognostic biomarker and inhibits the epithelial mesenchymal transition of oral squamous cell carcinoma through IL-6/STAT3 signaling pathway

• Published in: Journal of Cancer Vol. 11; no. 9; pp. 2621 - 2631
• Main Authors: Qu, Yi, He, Ying, Yang, Yang, Li, Shaoqing, An, Wei, Li, Zhilin, Wang, Xue, Han, Zhengxue, Qin, Lizheng
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2020; Ivyspring International Publisher
• Subjects: Antibodies; Cancer therapies; Cell growth; Gastric cancer; Gene expression; Head & neck cancer; Lung cancer; Lymphatic system; Medical prognosis; Membranes; Metastasis; Oral cancer; Proteins; Research Paper; Squamous cell carcinoma; Tumors; United States > US; China; ALDH3A1; prognostic biomarker; epithelial-mesenchymal transition; oral squamous cell carcinoma; IL-6; lymph node metastasis
• ISSN: 1837-9664; 1837-9664
• DOI: 10.7150/jca.40171

Aldehyde dehydrogenase 3A1 (ALDH3A1) is a member of the ALDH superfamily and its relationship with oral squamous cell carcinoma (OSCC) still unknown. In our subject, we aimed to reveal the expression pattern and clinical value of ALDH3A1 in OSCC and its biological function in OSCC cell lines. The ex...