Pioglitazone Improves Left Ventricular Diastolic Function in Subjects With Diabetes

• Published in: Diabetes care Vol. 40; no. 11; pp. 1530 - 1536
• Main Authors: Clarke, Geoffrey D., Solis-Herrera, Carolina, Molina-Wilkins, Marjorie, Martinez, Sandra, Merovci, Aurora, Cersosimo, Eugenio, Chilton, Robert J., Iozzo, Patricia, Gastaldelli, Amalia, Abdul-Ghani, Muhammad, DeFronzo, Ralph A.
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.11.2017
• Subjects: Adult; Blood Glucose - metabolism; Blood pressure; Blood Pressure - drug effects; Body Mass Index; Cardiac output; Cholesterol - blood; Contraction; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - drug therapy; Diastole - drug effects; Female; Glucose; Glucose Clamp Technique; Glucose tolerance; Glycated Hemoglobin - metabolism; Heart diseases; Heart rate; Humans; Hypoglycemic Agents - administration & dosage; Insulin; Insulin Resistance; Magnetic resonance imaging; Male; Middle Aged; Myocardium - metabolism; Pathophysiology/Complications; Perfusion; Pioglitazone; Positron emission; Positron emission tomography; Research design; Sensitivity; Stroke; Stroke volume; Stroke Volume - drug effects; Systole - drug effects; Thiazolidinediones - administration & dosage; Triglycerides - blood; Ventricle; Ventricular Function, Left - drug effects

To examine the effect of pioglitazone on myocardial insulin sensitivity and left ventricular (LV) function in patients with type 2 diabetes (T2D). Twelve subjects with T2D and 12 with normal glucose tolerance received a euglycemic insulin clamp. Myocardial glucose uptake (MGU) and myocardial perfusi...