Auditory dysfunction and cochlear vascular injury following trimethyltin exposure in the guinea pig

• Published in: Toxicology and applied pharmacology Vol. 105; no. 1; p. 133
• Main Authors: Fechter, L D, Carlisle, L
• Format: Journal Article
• Language: English
• Published: United States 01.08.1990
• Subjects: Animals; Auditory Threshold - drug effects; Cochlea - blood supply; Cochlea - drug effects; Evoked Potentials, Auditory - drug effects; Guinea Pigs; Hair Cells, Auditory - drug effects; Hearing Disorders - chemically induced; Stria Vascularis - drug effects; Stria Vascularis - pathology; Trialkyltin Compounds - toxicity; Trimethyltin Compounds - toxicity

Trimethyltin chloride (TMT) produces an auditory impairment in the rat due, presumably, to cochlear injury. The loss is unusual in that it persists for several weeks, but ultimately resolves at least at low to middle frequencies. Recovery of high frequency auditory loss is less predictable. Given th...