Human adipose mesenchymal stem cell-derived exosomal-miRNAs are critical factors for inducing anti-proliferation signalling to A2780 and SKOV-3 ovarian cancer cells

• Published in: Scientific reports Vol. 6; no. 1; p. 38498
• Main Authors: Reza, Abu Musa Md Talimur, Choi, Yun-Jung, Yasuda, Hideyo, Kim, Jin-Hoi
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 08.12.2016
• Subjects: Adipose Tissue - cytology; Apoptosis; Apoptosis - drug effects; Bax protein; Cell cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival - drug effects; Culture Media, Conditioned; Exosomes; Exosomes - metabolism; Exosomes - ultrastructure; Female; Gene Library; Gene Ontology; High-Throughput Nucleotide Sequencing; Humans; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; Mesenchyme; MicroRNAs - metabolism; miRNA; Mitochondria; Ovarian cancer; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Reproducibility of Results; Ribonuclease; Signal Transduction; Stem cells; Time Factors; Up-Regulation - drug effects; Wound healing; Wound Healing - drug effects

An enigmatic question exists concerning the pro- or anti-cancer status of mesenchymal stem cells (MSCs). Despite growing interest, this question remains unanswered, and the debate became intensified with new evidences backing each side. Here, we showed that human adipose MSC (hAMSC)-derived conditio...