Acute But Not Chronic Caffeine Impairs Functional Responses To Ischaemia-Reperfusion In Rat Isolated Perfused Heart

• Published in: Clinical and experimental pharmacology & physiology Vol. 28; no. 1-2; pp. 19 - 24
• Main Authors: Rose'Meyer, Roselyn B, Headrick, John P, Peart, Jason N, Harrison, Glenn J, Garnham, Bronwyn G, Willis, Roger J
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Science Pty 01.01.2001
• Subjects: adenosine; Animals; Arrhythmias, Cardiac - drug therapy; Blood Pressure - drug effects; Blood Pressure - physiology; caffeine; Caffeine - administration & dosage; Caffeine - pharmacology; Central Nervous System Stimulants - administration & dosage; Central Nervous System Stimulants - pharmacology; contraction amplitude; Coronary Vessels - drug effects; heart rate; Heart Rate - drug effects; Heart Rate - physiology; Male; Myocardial Ischemia - drug therapy; Myocardial Reperfusion; rat heart; Rats; Rats, Wistar; Time Factors

SUMMARY 1. The effect of acute (50 μmol/L) and chronic (0.06% in drinking water for 14 days) caffeine on the response to ischaemia–reperfusion was studied in Wistar rat isolated perfused hearts. 2. Neither acute nor chronic caffeine modified normoxic heart rate or left ventricular pressures. However...