Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease
Glucose metabolism is depressed in the temporal and parietal regions of the cortex in patients with Alzheimer's disease. We measured the concentrations of two glucose transporters, GLUT1 and GLUT3, in six regions of brains from both control subjects and patients with Alzheimer's disease. T...
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| Published in | Annals of neurology Vol. 35; no. 5; p. 546 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.05.1994
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Glucose metabolism is depressed in the temporal and parietal regions of the cortex in patients with Alzheimer's disease. We measured the concentrations of two glucose transporters, GLUT1 and GLUT3, in six regions of brains from both control subjects and patients with Alzheimer's disease. The concentrations of both transporters were reduced in the cerebral cortex, with larger and highly significant reductions observed for GLUT3, the putative neuronal glucose transporter. The reductions in GLUT3 were greater than the loss of synapses, and should be considered as a potential cause of the deficits in glucose metabolism. |
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| AbstractList | Glucose metabolism is depressed in the temporal and parietal regions of the cortex in patients with Alzheimer's disease. We measured the concentrations of two glucose transporters, GLUT1 and GLUT3, in six regions of brains from both control subjects and patients with Alzheimer's disease. The concentrations of both transporters were reduced in the cerebral cortex, with larger and highly significant reductions observed for GLUT3, the putative neuronal glucose transporter. The reductions in GLUT3 were greater than the loss of synapses, and should be considered as a potential cause of the deficits in glucose metabolism. |
| Author | Chundu, K R Honer, W G Davies, P Simpson, I A Davies-Hill, T |
| Author_xml | – sequence: 1 givenname: I A surname: Simpson fullname: Simpson, I A organization: Experimental Diabetes, Metabolism, and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD – sequence: 2 givenname: K R surname: Chundu fullname: Chundu, K R – sequence: 3 givenname: T surname: Davies-Hill fullname: Davies-Hill, T – sequence: 4 givenname: W G surname: Honer fullname: Honer, W G – sequence: 5 givenname: P surname: Davies fullname: Davies, P |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8179300$$D View this record in MEDLINE/PubMed |
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| PublicationTitle | Annals of neurology |
| PublicationTitleAlternate | Ann Neurol |
| PublicationYear | 1994 |
| References | 8179296 - Ann Neurol. 1994 May;35(5):511-2 |
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| Snippet | Glucose metabolism is depressed in the temporal and parietal regions of the cortex in patients with Alzheimer's disease. We measured the concentrations of two... |
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| SubjectTerms | Adult Aged Aged, 80 and over Alzheimer Disease - metabolism Brain - metabolism Caudate Nucleus - metabolism Cerebral Cortex - metabolism Glucose - metabolism Glucose Transporter Type 1 Glucose Transporter Type 3 Hippocampus - metabolism Humans Immunoblotting Middle Aged Monosaccharide Transport Proteins - analysis Nerve Tissue Proteins Reference Values |
| Title | Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/8179300 |
| Volume | 35 |
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