A comprehensive resequence-analysis of 250 kb region of 8q24.21 in men of African ancestry

• Published in: The Prostate Vol. 74; no. 6; pp. 579 - 589
• Main Authors: Chung, Charles C., Hsing, Ann W., Yeboah, Edward, Biritwum, Richard, Tettey, Yao, Adjei, Andrew, Cook, Michael B., De Marzo, Angelo, Netto, George, Tay, Evelyn, Boland, Joseph F., Yeager, Meredith, Chanock, Stephen J.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.05.2014
• Subjects: 8q24.21; Black or African American; Black People - genetics; Chromosomes, Human, Pair 8; Gene Frequency; Genetic Loci; Genetic Predisposition to Disease; genetics; Genome-Wide Association Study; Genotype; Haplotypes; Humans; Linkage Disequilibrium; Male; Polymorphism, Single Nucleotide; prostate cancer; Prostatic Neoplasms - genetics

BACKGROUND Genome‐wide association studies (GWAS) have identified that a ∼1 M region centromeric to the MYC oncogene on chromosome 8q24.21 harbors at least five independent loci associated with prostate cancer risk and additional loci associated with cancers of breast, colon, bladder, and chronic ly...