γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation

• Published in: Cell Vol. 166; no. 6; pp. 1485 - 1499.e15
• Main Authors: Daley, Donnele, Zambirinis, Constantinos Pantelis, Seifert, Lena, Akkad, Neha, Mohan, Navyatha, Werba, Gregor, Barilla, Rocky, Torres-Hernandez, Alejandro, Hundeyin, Mautin, Mani, Vishnu Raj Kumar, Avanzi, Antonina, Tippens, Daniel, Narayanan, Rajkishen, Jang, Jung-Eun, Newman, Elliot, Pillarisetty, Venu Gopal, Dustin, Michael Loran, Bar-Sagi, Dafna, Hajdu, Cristina, Miller, George
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.09.2016
• Subjects: Adaptive Immunity; adenocarcinoma; Animals; cancer; carcinogenesis; Carcinogenesis - immunology; Carcinogenesis - pathology; Carcinoma, Pancreatic Ductal - immunology; Carcinoma, Pancreatic Ductal - physiopathology; CD8-positive T-lymphocytes; Cells, Cultured; checkpoint ligands; chemokines; Chemokines - immunology; Epithelial Cells - physiology; Female; Humans; immune response; inflammation; Kras; Ligands; Lymphocyte Activation - immunology; Male; Mice; Mice, Inbred C57BL; Signal Transduction - immunology; T-Lymphocytes - immunology; Tumor Microenvironment - immunology; checkpoint ligands; cancer; Kras

Inflammation is paramount in pancreatic oncogenesis. We identified a uniquely activated γδT cell population, which constituted ∼40% of tumor-infiltrating T cells in human pancreatic ductal adenocarcinoma (PDA). Recruitment and activation of γδT cells was contingent on diverse chemokine signals. Dele...