Production of Reactive Oxygen Species in Neutrophils after Repeated Bouts of Exercise in Standardbred Trotters
Six trained Standardbred trotters exercised on a racetrack on 2 days with a 3‐day interval. On both exercise days the horses trotted three different exercise bouts with increasing intensity with 60‐min intervals. Exercise‐induced stress was manifested as leucocytosis, an increase in the neutrophil :...
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Published in | Journal of veterinary medicine. Series A Vol. 47; no. 9; pp. 565 - 573 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Science, Ltd
01.11.2000
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Subjects | |
Online Access | Get full text |
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Summary: | Six trained Standardbred trotters exercised on a racetrack on 2 days with a 3‐day interval. On both exercise days the horses trotted three different exercise bouts with increasing intensity with 60‐min intervals. Exercise‐induced stress was manifested as leucocytosis, an increase in the neutrophil : lymphocyte (N : L) ratio, and increased capacity to produce reactive oxygen species in the peripheral blood as indicated by an increase in whole blood chemiluminescence. The leucocytosis was mainly due to neutrophilia, which lasted for 6 h. Production of reactive oxygen species per single neutrophil showed no significant change during a day of exercise, but was lower on the second exercise day. The cortisol concentrations and N : L ratio, used as indicators of stress, behaved differently: Cortisol did not change significantly after exercise, whereas the N : L ratio increased. These results suggest that in trained horses, the N : L ratio is a sensitive indicator of stress of short duration, and an attenuated N : L response can be taken as an indicator of adaptation to exercise stress. |
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Bibliography: | ark:/67375/WNG-1VN8NQTF-D ArticleID:TBED275 istex:A44CF3B807FF531361EA09A0C41658F08E9E5AA8 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0931-184X 1439-0442 |
DOI: | 10.1046/j.1439-0442.2000.00275.x |