Serum alkaline phosphatase isoenzyme profiles in phenobarbital-treated epileptic dogs

• Published in: Veterinary clinical pathology Vol. 33; no. 4; pp. 215 - 222
• Main Authors: Gaskill, C.L, Hoffmann, W.E, Cribb, A.E
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2004
• Subjects: Alkaline phosphatase; Alkaline Phosphatase - blood; Animals; Anticonvulsants - adverse effects; blood chemistry; blood serum; bones; canine; corticosterone; Cross-Sectional Studies; dog; dog diseases; Dog Diseases - drug therapy; Dog Diseases - enzymology; Dogs; drug evaluation; enzyme activity; epilepsy; Epilepsy - drug therapy; Epilepsy - enzymology; Epilepsy - veterinary; isoenzyme; Isoenzymes - blood; isoform; isozymes; liver; phenobarbital; Phenobarbital - adverse effects; Prospective Studies; veterinary medicine

Background: Serum total alkaline phosphatase (AP) activity commonly is high in dogs receiving phenobarbital. Specific isoenzymes responsible for this increase are not well documented. Objectives: The purposes of this study were 1) to qualitatively and quantitatively describe serum AP isoenzymes in p...