Low numbers and no loss of melanized nigral neurons with increasing age in normal human brains from India

• Published in: Annals of neurology Vol. 43; no. 3; p. 283
• Main Authors: Muthane, U, Yasha, T C, Shankar, S K
• Format: Journal Article
• Language: English
• Published: United States 01.03.1998
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Aging - physiology; Cell Count; Child; Child, Preschool; Female; Humans; India - ethnology; Infant; Infant, Newborn; Male; Melanins - metabolism; Middle Aged; Reference Values; Substantia Nigra - cytology; Substantia Nigra - metabolism; India

The prevalence of Parkinson's disease (PD) is higher in whites than in nonwhites and it increases with advancing age. The pathological hallmarks of PD are loss of pigmented neurons in the substantia nigra pars compacta (SNpc) and presence of Lewy bodies. With increasing age, a similar loss of p...